Regulation of presynaptic Ca(2+) channel abundance at active zones through a balance of delivery and turnover

Voltage-gated Ca(2+) channels (VGCCs) mediate Ca(2+) influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (P(r)), a key presynaptic determinant of synaptic strength. Althoug...

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Detalles Bibliográficos
Autores principales: Cunningham, Karen L, Sauvola, Chad W, Tavana, Sara, Littleton, J Troy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352347/
https://www.ncbi.nlm.nih.gov/pubmed/35833625
http://dx.doi.org/10.7554/eLife.78648

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