circMbl functions in cis and in trans to regulate gene expression and physiology in a tissue-specific fashion

Muscleblind (mbl) is an essential muscle and neuronal splicing regulator. Mbl hosts multiple circular RNAs (circRNAs), including circMbl, which is conserved from flies to humans. Here, we show that mbl-derived circRNAs are key regulators of MBL by cis- and trans-acting mechanisms. By generating fly...

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Detalles Bibliográficos
Autores principales: Pamudurti, Nagarjuna Reddy, Patop, Ines Lucia, Krishnamoorthy, Aishwarya, Bartok, Osnat, Maya, Roni, Lerner, Noam, Ashwall-Fluss, Reut, Konakondla, Jacob Vinay Vikas, Beatus, Tsevi, Kadener, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352392/
https://www.ncbi.nlm.nih.gov/pubmed/35476987
http://dx.doi.org/10.1016/j.celrep.2022.110740

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