Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy

Accumulating evidence has showed that sushi-repeat-containing protein X-linked 2 (SRPX2) is an abnormal expression in a variety of cancers and involved in cancer carcinogenesis, chemosensitivity, and prognosis, which mainly promote cancer cell metastasis, invasion, and migration by regulating the uP...

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Detalles Bibliográficos
Autores principales: Chen, Jinhua, Yin, Zhenhua, Song, Wenping, He, Baoxia, Zhang, Wenzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352485/
https://www.ncbi.nlm.nih.gov/pubmed/35935582
http://dx.doi.org/10.1155/2022/2931214
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author Chen, Jinhua
Yin, Zhenhua
Song, Wenping
He, Baoxia
Zhang, Wenzhou
author_facet Chen, Jinhua
Yin, Zhenhua
Song, Wenping
He, Baoxia
Zhang, Wenzhou
author_sort Chen, Jinhua
collection PubMed
description Accumulating evidence has showed that sushi-repeat-containing protein X-linked 2 (SRPX2) is an abnormal expression in a variety of cancers and involved in cancer carcinogenesis, chemosensitivity, and prognosis, which mainly promote cancer cell metastasis, invasion, and migration by regulating the uPAR/integrins/FAK signaling pathway, epithelial-mesenchymal transition (EMT), angiogenesis, and glycosylation. Inflammation has been regarded as a key role in regulating cancer initiation, progression, EMT, and therapeutics. Furthermore, SRPX2 exhibited excellent antifibrosis effect via the TGFβR1/SMAD3/SRPX2/AP1/SMAD7 signaling pathway. Therefore, this review provides compelling evidence that SRPX2 might be a therapeutic target for inflammation and cancer-related inflammation for future cancer therapeutics.
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spelling pubmed-93524852022-08-05 Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy Chen, Jinhua Yin, Zhenhua Song, Wenping He, Baoxia Zhang, Wenzhou J Immunol Res Review Article Accumulating evidence has showed that sushi-repeat-containing protein X-linked 2 (SRPX2) is an abnormal expression in a variety of cancers and involved in cancer carcinogenesis, chemosensitivity, and prognosis, which mainly promote cancer cell metastasis, invasion, and migration by regulating the uPAR/integrins/FAK signaling pathway, epithelial-mesenchymal transition (EMT), angiogenesis, and glycosylation. Inflammation has been regarded as a key role in regulating cancer initiation, progression, EMT, and therapeutics. Furthermore, SRPX2 exhibited excellent antifibrosis effect via the TGFβR1/SMAD3/SRPX2/AP1/SMAD7 signaling pathway. Therefore, this review provides compelling evidence that SRPX2 might be a therapeutic target for inflammation and cancer-related inflammation for future cancer therapeutics. Hindawi 2022-07-28 /pmc/articles/PMC9352485/ /pubmed/35935582 http://dx.doi.org/10.1155/2022/2931214 Text en Copyright © 2022 Jinhua Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Jinhua
Yin, Zhenhua
Song, Wenping
He, Baoxia
Zhang, Wenzhou
Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy
title Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy
title_full Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy
title_fullStr Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy
title_full_unstemmed Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy
title_short Sushi-Repeat-Containing Protein X-Linked 2: A Potential Therapeutic Target for Inflammation and Cancer Therapy
title_sort sushi-repeat-containing protein x-linked 2: a potential therapeutic target for inflammation and cancer therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352485/
https://www.ncbi.nlm.nih.gov/pubmed/35935582
http://dx.doi.org/10.1155/2022/2931214
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