The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon

The Cullin-RING ligase 4 E3 ubiquitin ligase component Cereblon (CRBN) is a well-established target for a class of small molecules termed immunomodulatory drugs (IMiDs). These drugs drive CRBN to modulate the degradation of a number of neosubstrates required for the growth of multiple cancers. Where...

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Detalles Bibliográficos
Autores principales: Shen, Chen, Nayak, Anmada, Neitzel, Leif R., Yang, Fan, Li, Bin, Williams, Charles H., Hong, Charles C., Ahmed, Yashi, Lee, Ethan, Robbins, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Accelerated Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352546/
https://www.ncbi.nlm.nih.gov/pubmed/35780831
http://dx.doi.org/10.1016/j.jbc.2022.102227

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