Clathrin adaptor AP-1–mediated Golgi export of amyloid precursor protein is crucial for the production of neurotoxic amyloid fragments

One of the hallmarks of Alzheimer’s disease is the accumulation of toxic amyloid-β (Aβ) peptides in extracellular plaques. The direct precursor of Aβ is the carboxyl-terminal fragment β (or C99) of the amyloid precursor protein (APP). C99 is detected at elevated levels in Alzheimer’s disease brains,...

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Detalles Bibliográficos
Autores principales: Januário, Yunan C., Eden, Jessica, de Oliveira, Luan S., De Pace, Raffaella, Tavares, Lucas A., da Silva-Januário, Mara E., Apolloni, Vinícius B., Wilby, Elise L., Altmeyer, Randolf, Burgos, Patricia V., Corrêa, Sonia A.L., Gershlick, David C., daSilva, Luis L.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352552/
https://www.ncbi.nlm.nih.gov/pubmed/35753347
http://dx.doi.org/10.1016/j.jbc.2022.102172

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