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Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver

Activation of the constitutive androstane receptor (CAR) may induce adaptive but also adverse effects in rodent liver, including the induction of drug-metabolizing enzymes, transient hepatocellular proliferation, and promotion of liver tumor growth. Human relevance of CAR-related adverse hepatic eff...

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Detalles Bibliográficos
Autores principales:	Sprenger, Heike, Rasinger, Josef Daniel, Hammer, Helen, Naboulsi, Wael, Zabinsky, Elke, Planatscher, Hannes, Schwarz, Michael, Poetz, Oliver, Braeuning, Albert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Toxicogenomics and Omics Technologies
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352639/ https://www.ncbi.nlm.nih.gov/pubmed/35881160 http://dx.doi.org/10.1007/s00204-022-03338-7

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