Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection

The DNA polymerase theta (Polθ)-mediated end joining (TMEJ) pathway for repair of chromosomal double strand breaks (DSBs) is essential in cells deficient in other DSB repair pathways, including hereditary breast cancers defective in homologous recombination. Strand-break activated poly(ADP) ribose p...

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Detalles Bibliográficos
Autores principales: Luedeman, Megan E., Stroik, Susanna, Feng, Wanjuan, Luthman, Adam J., Gupta, Gaorav P., Ramsden, Dale A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352658/
https://www.ncbi.nlm.nih.gov/pubmed/35927262
http://dx.doi.org/10.1038/s41467-022-32166-7

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