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Molecular characterization of colorectal cancer related peritoneal metastatic disease
A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the mole...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352687/ https://www.ncbi.nlm.nih.gov/pubmed/35927254 http://dx.doi.org/10.1038/s41467-022-32198-z |
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| author | Lenos, Kristiaan J. Bach, Sander Ferreira Moreno, Leandro ten Hoorn, Sanne Sluiter, Nina R. Bootsma, Sanne Vieira Braga, Felipe A. Nijman, Lisanne E. van den Bosch, Tom Miedema, Daniel M. van Dijk, Erik Ylstra, Bauke Kulicke, Ruth Davis, Fred P. Stransky, Nicolas Smolen, Gromoslaw A. Coebergh van den Braak, Robert R. J. IJzermans, Jan N. M. Martens, John W. M. Hallam, Sally Beggs, Andrew D. Kops, Geert J. P. L. Lansu, Nico Bastiaenen, Vivian P. Klaver, Charlotte E. L. Lecca, Maria C. El Makrini, Khalid Elbers, Clara C. Dings, Mark P. G. van Noesel, Carel J. M. Kranenburg, Onno Medema, Jan Paul Koster, Jan Koens, Lianne Punt, Cornelis J. A. Tanis, Pieter J. de Hingh, Ignace H. Bijlsma, Maarten F. Tuynman, Jurriaan B. Vermeulen, Louis |
| author_facet | Lenos, Kristiaan J. Bach, Sander Ferreira Moreno, Leandro ten Hoorn, Sanne Sluiter, Nina R. Bootsma, Sanne Vieira Braga, Felipe A. Nijman, Lisanne E. van den Bosch, Tom Miedema, Daniel M. van Dijk, Erik Ylstra, Bauke Kulicke, Ruth Davis, Fred P. Stransky, Nicolas Smolen, Gromoslaw A. Coebergh van den Braak, Robert R. J. IJzermans, Jan N. M. Martens, John W. M. Hallam, Sally Beggs, Andrew D. Kops, Geert J. P. L. Lansu, Nico Bastiaenen, Vivian P. Klaver, Charlotte E. L. Lecca, Maria C. El Makrini, Khalid Elbers, Clara C. Dings, Mark P. G. van Noesel, Carel J. M. Kranenburg, Onno Medema, Jan Paul Koster, Jan Koens, Lianne Punt, Cornelis J. A. Tanis, Pieter J. de Hingh, Ignace H. Bijlsma, Maarten F. Tuynman, Jurriaan B. Vermeulen, Louis |
| author_sort | Lenos, Kristiaan J. |
| collection | PubMed |
| description | A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity. |
| format | Online Article Text |
| id | pubmed-9352687 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-93526872022-08-06 Molecular characterization of colorectal cancer related peritoneal metastatic disease Lenos, Kristiaan J. Bach, Sander Ferreira Moreno, Leandro ten Hoorn, Sanne Sluiter, Nina R. Bootsma, Sanne Vieira Braga, Felipe A. Nijman, Lisanne E. van den Bosch, Tom Miedema, Daniel M. van Dijk, Erik Ylstra, Bauke Kulicke, Ruth Davis, Fred P. Stransky, Nicolas Smolen, Gromoslaw A. Coebergh van den Braak, Robert R. J. IJzermans, Jan N. M. Martens, John W. M. Hallam, Sally Beggs, Andrew D. Kops, Geert J. P. L. Lansu, Nico Bastiaenen, Vivian P. Klaver, Charlotte E. L. Lecca, Maria C. El Makrini, Khalid Elbers, Clara C. Dings, Mark P. G. van Noesel, Carel J. M. Kranenburg, Onno Medema, Jan Paul Koster, Jan Koens, Lianne Punt, Cornelis J. A. Tanis, Pieter J. de Hingh, Ignace H. Bijlsma, Maarten F. Tuynman, Jurriaan B. Vermeulen, Louis Nat Commun Article A significant proportion of colorectal cancer (CRC) patients develop peritoneal metastases (PM) in the course of their disease. PMs are associated with a poor quality of life, significant morbidity and dismal disease outcome. To improve care for this patient group, a better understanding of the molecular characteristics of CRC-PM is required. Here we present a comprehensive molecular characterization of a cohort of 52 patients. This reveals that CRC-PM represent a distinct CRC molecular subtype, CMS4, but can be further divided in three separate categories, each presenting with unique features. We uncover that the CMS4-associated structural protein Moesin plays a key role in peritoneal dissemination. Finally, we define specific evolutionary features of CRC-PM which indicate that polyclonal metastatic seeding underlies these lesions. Together our results suggest that CRC-PM should be perceived as a distinct disease entity. Nature Publishing Group UK 2022-08-04 /pmc/articles/PMC9352687/ /pubmed/35927254 http://dx.doi.org/10.1038/s41467-022-32198-z Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Article Lenos, Kristiaan J. Bach, Sander Ferreira Moreno, Leandro ten Hoorn, Sanne Sluiter, Nina R. Bootsma, Sanne Vieira Braga, Felipe A. Nijman, Lisanne E. van den Bosch, Tom Miedema, Daniel M. van Dijk, Erik Ylstra, Bauke Kulicke, Ruth Davis, Fred P. Stransky, Nicolas Smolen, Gromoslaw A. Coebergh van den Braak, Robert R. J. IJzermans, Jan N. M. Martens, John W. M. Hallam, Sally Beggs, Andrew D. Kops, Geert J. P. L. Lansu, Nico Bastiaenen, Vivian P. Klaver, Charlotte E. L. Lecca, Maria C. El Makrini, Khalid Elbers, Clara C. Dings, Mark P. G. van Noesel, Carel J. M. Kranenburg, Onno Medema, Jan Paul Koster, Jan Koens, Lianne Punt, Cornelis J. A. Tanis, Pieter J. de Hingh, Ignace H. Bijlsma, Maarten F. Tuynman, Jurriaan B. Vermeulen, Louis Molecular characterization of colorectal cancer related peritoneal metastatic disease |
| title | Molecular characterization of colorectal cancer related peritoneal metastatic disease |
| title_full | Molecular characterization of colorectal cancer related peritoneal metastatic disease |
| title_fullStr | Molecular characterization of colorectal cancer related peritoneal metastatic disease |
| title_full_unstemmed | Molecular characterization of colorectal cancer related peritoneal metastatic disease |
| title_short | Molecular characterization of colorectal cancer related peritoneal metastatic disease |
| title_sort | molecular characterization of colorectal cancer related peritoneal metastatic disease |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352687/ https://www.ncbi.nlm.nih.gov/pubmed/35927254 http://dx.doi.org/10.1038/s41467-022-32198-z |
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