Deficiency of WTAP in hepatocytes induces lipoatrophy and non-alcoholic steatohepatitis (NASH)

Ectopic lipid accumulation and inflammation are the essential signs of NASH. However, the molecular mechanisms of ectopic lipid accumulation and inflammation during NASH progression are not fully understood. Here we reported that hepatic Wilms' tumor 1-associating protein (WTAP) is a key integr...

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Detalles Bibliográficos
Autores principales: Li, Xinzhi, Ding, Kaixin, Li, Xueying, Yuan, Bingchuan, Wang, Yuqin, Yao, Zhicheng, Wang, Shuaikang, Huang, He, Xu, Bolin, Xie, Liwei, Deng, Tuo, Chen, Xiao-wei, Chen, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352699/
https://www.ncbi.nlm.nih.gov/pubmed/35927268
http://dx.doi.org/10.1038/s41467-022-32163-w

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