Cargando…

Structural insights into Cas9 mismatch: promising for development of high-fidelity Cas9 variants

Detalles Bibliográficos
Autores principales:	Tang, Honghai, Wang, Daqi, Shu, Yilai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Research Highlight
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352718/ https://www.ncbi.nlm.nih.gov/pubmed/35927241 http://dx.doi.org/10.1038/s41392-022-01139-z

Ejemplares similares

Structural insights into a high fidelity variant of SpCas9
por: Guo, Minghui, et al.
Publicado: (2019)

Smash and DASH with Cas9
por: Ramani, Vijay, et al.
Publicado: (2016)

High-fidelity KKH variant of Staphylococcus aureus Cas9 nucleases with improved base mismatch discrimination
por: Yuen, Chaya T L, et al.
Publicado: (2022)

Development of a high-fidelity Cas9-dependent adenine base editor (ABE) system for genome editing with high-fidelity Cas9 variants
por: Hong, Ruisha, et al.
Publicado: (2022)

Optimized CRISPR guide RNA design for two high-fidelity Cas9 variants by deep learning
por: Wang, Daqi, et al.
Publicado: (2019)

The impact of nucleosome structure on CRISPR/Cas9 fidelity
por: Handelmann, Christopher R, et al.
Publicado: (2023)

FrCas9 is a CRISPR/Cas9 system with high editing efficiency and fidelity
por: Cui, Zifeng, et al.
Publicado: (2022)

Structural basis for mismatch surveillance by CRISPR–Cas9
por: Bravo, Jack P. K., et al.
Publicado: (2022)

Redefining mouse transgenesis with CRISPR/Cas9 genome editing technology
por: Burgio, Gaetan
Publicado: (2018)

Sniper2L is a high-fidelity Cas9 variant with high activity
por: Kim, Young-hoon, et al.
Publicado: (2023)

High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets
por: Kleinstiver, Benjamin P., et al.
Publicado: (2016)

Multiplex nucleotide editing by high-fidelity Cas9 variants with improved efficiency in rice
por: Xu, Wen, et al.
Publicado: (2019)

Publisher Correction: Structural basis for mismatch surveillance by CRISPR–Cas9
por: Bravo, Jack P. K., et al.
Publicado: (2022)

Pop in, pop out: a novel gene-targeting strategy for use with CRISPR-Cas9
por: Kühn, Ralf, et al.
Publicado: (2015)

NmeCas9 is an intrinsically high-fidelity genome-editing platform
por: Amrani, Nadia, et al.
Publicado: (2018)

CRISPR/Cas9 offers a new tool for studying the role of chromatin architecture in disease pathogenesis
por: Guo, Xiang, et al.
Publicado: (2018)

Protein stability regulators screening assay (Pro-SRSA): protein degradation meets the CRISPR–Cas9 library
por: Wu, Yuanzhong, et al.
Publicado: (2016)

Distinct patterns of Cas9 mismatch tolerance in vitro and in vivo
por: Fu, Becky X.H., et al.
Publicado: (2016)

High-fidelity SaCas9 identified by directional screening in human cells
por: Xie, Haihua, et al.
Publicado: (2020)

Precise detection of CRISPR-Cas9 editing in hair cells in the treatment of autosomal dominant hearing loss
por: Cui, Chong, et al.
Publicado: (2022)

Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage
por: Kulcsár, Péter István, et al.
Publicado: (2017)

Kinetics and Fidelity of the Repair of Cas9-Induced Double-Strand DNA Breaks
por: Brinkman, Eva K., et al.
Publicado: (2018)

Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease
por: Chen, Weizhong, et al.
Publicado: (2019)

A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope
por: Hu, Ziying, et al.
Publicado: (2020)

High-fidelity endonuclease variant HypaCas9 facilitates accurate allele-specific gene modification in mouse zygotes
por: Ikeda, Arisa, et al.
Publicado: (2019)

Computational normal mode analysis accurately replicates the activity and specificity profiles of CRISPR-Cas9 and high-fidelity variants
por: Shor, Oded, et al.
Publicado: (2022)

A cleavage rule for selection of increased-fidelity SpCas9 variants with high efficiency and no detectable off-targets
por: Kulcsár, Péter István, et al.
Publicado: (2023)

CCR5-Δ32 biology, gene editing, and warnings for the future of CRISPR-Cas9 as a human and humane gene editing tool
por: Xu, MengMeng
Publicado: (2020)

Boosting plant immunity with CRISPR/Cas
por: Chaparro-Garcia, Angela, et al.
Publicado: (2015)

CRISPR-Cas9 for in vivo Gene Therapy: Promise and Hurdles
por: Dai, Wei-Jing, et al.
Publicado: (2016)

Advantages of using the CRISPR/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models
por: Young, Samantha AM, et al.
Publicado: (2015)

Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects
por: Gopalakrishna, Kathyayini P., et al.
Publicado: (2023)

Targeting PCSK9: a promising adjuvant strategy in cancer immunotherapy
por: Almeida, Catarina R., et al.
Publicado: (2021)

Structural insights into DNA cleavage activation of CRISPR-Cas9 system
por: Huai, Cong, et al.
Publicado: (2017)

Active-Site Models of Streptococcus pyogenes Cas9 in DNA Cleavage State
por: Tang, Honghai, et al.
Publicado: (2021)

Highly parallel genome variant engineering with CRISPR/Cas9
por: Sadhu, Meru J., et al.
Publicado: (2018)

Spontaneous Embedding of DNA Mismatches Within the RNA:DNA Hybrid of CRISPR-Cas9
por: Mitchell, Brandon P., et al.
Publicado: (2020)

Strategies in the delivery of Cas9 ribonucleoprotein for CRISPR/Cas9 genome editing
por: Zhang, Song, et al.
Publicado: (2021)

Engineering of temperature- and light-switchable Cas9 variants
por: Richter, Florian, et al.
Publicado: (2016)

Research highlights for issue 6: the CRISPR/Cas revolution
por: Koskella, Britt
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_sc5ef5rks3bjskjl0vvh3i3umg