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Interaction between transcribing RNA polymerase and topoisomerase I prevents R-loop formation in E. coli

Bacterial topoisomerase I (TopoI) removes excessive negative supercoiling and is thought to relax DNA molecules during transcription, replication and other processes. Using ChIP-Seq, we show that TopoI of Escherichia coli (EcTopoI) is colocalized, genome-wide, with transcribing RNA polymerase (RNAP)...

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Detalles Bibliográficos
Autores principales:	Sutormin, Dmitry, Galivondzhyan, Alina, Musharova, Olga, Travin, Dmitrii, Rusanova, Anastasiia, Obraztsova, Kseniya, Borukhov, Sergei, Severinov, Konstantin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352719/ https://www.ncbi.nlm.nih.gov/pubmed/35927234 http://dx.doi.org/10.1038/s41467-022-32106-5

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