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Ligand-specific conformational change drives interdomain allostery in Pin1

Pin1 is a two-domain cell regulator that isomerizes peptidyl-prolines. The catalytic domain (PPIase) and the other ligand-binding domain (WW) sample extended and compact conformations. Ligand binding changes the equilibrium of the interdomain conformations, but the conformational changes that lead t...

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Detalles Bibliográficos
Autores principales:	Born, Alexandra, Soetbeer, Janne, Henen, Morkos A., Breitgoff, Frauke, Polyhach, Yevhen, Jeschke, Gunnar, Vögeli, Beat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352728/ https://www.ncbi.nlm.nih.gov/pubmed/35927276 http://dx.doi.org/10.1038/s41467-022-32340-x

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