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Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report
BACKGROUND: Primary cancer of the appendix, especially signet-ring cell carcinoma, is an uncommon disease, and it is rarely suspected before surgery. Diffuse intestinal ganglioneuromatosis that is not associated with neurofibromatosis-1 or multiple endocrine neoplasia 2b is also rare. The most frequ...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352829/ https://www.ncbi.nlm.nih.gov/pubmed/35927360 http://dx.doi.org/10.1186/s40792-022-01509-3 |
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author | Sato, Ayami Sato, Yu Hiruta, Nobuyuki Oshiro, Takashi Yoshida, Yutaka Urita, Tasuku Kitahara, Tomoaki Kadoya, Kengo Nabekura, Taiki Moriyama, Yuki Okazumi, Shinichi |
author_facet | Sato, Ayami Sato, Yu Hiruta, Nobuyuki Oshiro, Takashi Yoshida, Yutaka Urita, Tasuku Kitahara, Tomoaki Kadoya, Kengo Nabekura, Taiki Moriyama, Yuki Okazumi, Shinichi |
author_sort | Sato, Ayami |
collection | PubMed |
description | BACKGROUND: Primary cancer of the appendix, especially signet-ring cell carcinoma, is an uncommon disease, and it is rarely suspected before surgery. Diffuse intestinal ganglioneuromatosis that is not associated with neurofibromatosis-1 or multiple endocrine neoplasia 2b is also rare. The most frequent symptoms caused by it are changes in bowel habits, abdominal pain, and occlusive episodes. CASE PRESENTATION: The patient was a 48-year-old woman who had a month-long history of chronic abdominal pain, fullness, constipation, and diarrhoea. Enhanced computed tomography showed a 100-mm irregular swelling in the appendix and thickening of the appendiceal wall with cystic dilatation. Based on a preoperative diagnosis of appendiceal cancer, the patient underwent laparoscopic ileocecal resection with D3 lymph node dissection. Pathological diagnosis revealed a signet-ring cell carcinoma of the appendix with ganglioneuromatosis. The patient completed four courses of capecitabine plus oxaliplatin (CAPEOX) as postoperative adjuvant chemotherapy, and 23-month postoperative outcome was noneventful without recurrence. CONCLUSION: We report a signet-ring cell carcinoma of the appendix that was detected early because of its presence with ganglioneuromatosis. |
format | Online Article Text |
id | pubmed-9352829 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-93528292022-08-06 Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report Sato, Ayami Sato, Yu Hiruta, Nobuyuki Oshiro, Takashi Yoshida, Yutaka Urita, Tasuku Kitahara, Tomoaki Kadoya, Kengo Nabekura, Taiki Moriyama, Yuki Okazumi, Shinichi Surg Case Rep Case Report BACKGROUND: Primary cancer of the appendix, especially signet-ring cell carcinoma, is an uncommon disease, and it is rarely suspected before surgery. Diffuse intestinal ganglioneuromatosis that is not associated with neurofibromatosis-1 or multiple endocrine neoplasia 2b is also rare. The most frequent symptoms caused by it are changes in bowel habits, abdominal pain, and occlusive episodes. CASE PRESENTATION: The patient was a 48-year-old woman who had a month-long history of chronic abdominal pain, fullness, constipation, and diarrhoea. Enhanced computed tomography showed a 100-mm irregular swelling in the appendix and thickening of the appendiceal wall with cystic dilatation. Based on a preoperative diagnosis of appendiceal cancer, the patient underwent laparoscopic ileocecal resection with D3 lymph node dissection. Pathological diagnosis revealed a signet-ring cell carcinoma of the appendix with ganglioneuromatosis. The patient completed four courses of capecitabine plus oxaliplatin (CAPEOX) as postoperative adjuvant chemotherapy, and 23-month postoperative outcome was noneventful without recurrence. CONCLUSION: We report a signet-ring cell carcinoma of the appendix that was detected early because of its presence with ganglioneuromatosis. Springer Berlin Heidelberg 2022-08-05 /pmc/articles/PMC9352829/ /pubmed/35927360 http://dx.doi.org/10.1186/s40792-022-01509-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Case Report Sato, Ayami Sato, Yu Hiruta, Nobuyuki Oshiro, Takashi Yoshida, Yutaka Urita, Tasuku Kitahara, Tomoaki Kadoya, Kengo Nabekura, Taiki Moriyama, Yuki Okazumi, Shinichi Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
title | Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
title_full | Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
title_fullStr | Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
title_full_unstemmed | Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
title_short | Signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
title_sort | signet-ring cell carcinoma of the appendix with ganglioneuromatosis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352829/ https://www.ncbi.nlm.nih.gov/pubmed/35927360 http://dx.doi.org/10.1186/s40792-022-01509-3 |
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