Bruton’s tyrosine kinase phosphorylates scaffolding and RNA-binding protein G3BP1 to induce stress granule aggregation during host sensing of foreign ribonucleic acids

The Ras-GTPase activating protein SH3 domain-binding protein 1 (G3BP1) plays a critical role in the formation of classical and antiviral stress granules in stressed and virus-infected eukaryotic cells, respectively. While G3BP1 is known to be phosphorylated at serine residues which could affect stre...

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Detalles Bibliográficos
Autores principales: Kim, Susana S-Y., Sim, Don C.N., Carissimo, Guillaume, Lim, Hong-Hwa, Lam, Kong-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352910/
https://www.ncbi.nlm.nih.gov/pubmed/35798143
http://dx.doi.org/10.1016/j.jbc.2022.102231

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