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Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity

The complement system is a part of the innate immune system, where it labels intruding pathogens as well as dying host cells for clearance. If complement regulation is compromised, the system may contribute to pathogenesis. The proteolytic fragment C3b of complement component C3, is the pivot point...

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Detalles Bibliográficos
Autores principales:	Pedersen, Henrik, Jensen, Rasmus Kjeldsen, Hansen, Annette Gudmann, Petersen, Steen Vang, Thiel, Steffen, Laursen, Nick Stub, Andersen, Gregers Rom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352930/ https://www.ncbi.nlm.nih.gov/pubmed/35935935 http://dx.doi.org/10.3389/fimmu.2022.872536

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