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Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorph...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352942/ https://www.ncbi.nlm.nih.gov/pubmed/35938025 http://dx.doi.org/10.3389/fgene.2022.899124 |
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author | Hu, Baoping Wang, Yuhe Wang, Zhongtao He, Xue Wang, Li Yuan, Dongya He, Yongjun Jin, Tianbo He, Shumei |
author_facet | Hu, Baoping Wang, Yuhe Wang, Zhongtao He, Xue Wang, Li Yuan, Dongya He, Yongjun Jin, Tianbo He, Shumei |
author_sort | Hu, Baoping |
collection | PubMed |
description | Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorphisms in or near the SLC11A1 gene and susceptibility to TB. The Agena MassARRAY platform was conducted for genotyping from 510 TB patients and 508 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through logistic regression adjustment age and gender to assess the relationships between polymorphisms and TB risk. Our results identified that rs7608307 was related to increased TB risk in males (CT vs. CC: OR = 1.69, 95%CI: 1.12–2.56, p = 0.013; CT-TT vs. CC: OR = 1.61, 95%CI: 1.08–2.41, p = 0.020) and age ≤41 group (CT vs. CC: OR = 1.66, 95%CI: 1.04–2.65, p = 0.035), respectively. The SNP rs13062 was associated with the TB risk both in males (p = 0.012) and age >41 group (p = 0.021). In addition, we observed that the CC genotype of rs4674301 was correlated with increased TB risk in females (p = 0.043). Our results demonstrated the relationships between polymorphisms (rs7608307, rs4674301, and rs13062) in or near the SLC11A1 gene and age- and sex-specific TB risk in the northwest Chinese Han population. |
format | Online Article Text |
id | pubmed-9352942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93529422022-08-06 Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population Hu, Baoping Wang, Yuhe Wang, Zhongtao He, Xue Wang, Li Yuan, Dongya He, Yongjun Jin, Tianbo He, Shumei Front Genet Genetics Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorphisms in or near the SLC11A1 gene and susceptibility to TB. The Agena MassARRAY platform was conducted for genotyping from 510 TB patients and 508 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through logistic regression adjustment age and gender to assess the relationships between polymorphisms and TB risk. Our results identified that rs7608307 was related to increased TB risk in males (CT vs. CC: OR = 1.69, 95%CI: 1.12–2.56, p = 0.013; CT-TT vs. CC: OR = 1.61, 95%CI: 1.08–2.41, p = 0.020) and age ≤41 group (CT vs. CC: OR = 1.66, 95%CI: 1.04–2.65, p = 0.035), respectively. The SNP rs13062 was associated with the TB risk both in males (p = 0.012) and age >41 group (p = 0.021). In addition, we observed that the CC genotype of rs4674301 was correlated with increased TB risk in females (p = 0.043). Our results demonstrated the relationships between polymorphisms (rs7608307, rs4674301, and rs13062) in or near the SLC11A1 gene and age- and sex-specific TB risk in the northwest Chinese Han population. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9352942/ /pubmed/35938025 http://dx.doi.org/10.3389/fgene.2022.899124 Text en Copyright © 2022 Hu, Wang, Wang, He, Wang, Yuan, He, Jin and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Hu, Baoping Wang, Yuhe Wang, Zhongtao He, Xue Wang, Li Yuan, Dongya He, Yongjun Jin, Tianbo He, Shumei Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population |
title | Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population |
title_full | Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population |
title_fullStr | Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population |
title_full_unstemmed | Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population |
title_short | Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population |
title_sort | association of slc11a1 polymorphisms with tuberculosis susceptibility in the chinese han population |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352942/ https://www.ncbi.nlm.nih.gov/pubmed/35938025 http://dx.doi.org/10.3389/fgene.2022.899124 |
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