Cargando…

Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population

Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorph...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Baoping, Wang, Yuhe, Wang, Zhongtao, He, Xue, Wang, Li, Yuan, Dongya, He, Yongjun, Jin, Tianbo, He, Shumei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352942/
https://www.ncbi.nlm.nih.gov/pubmed/35938025
http://dx.doi.org/10.3389/fgene.2022.899124
_version_ 1784762760899330048
author Hu, Baoping
Wang, Yuhe
Wang, Zhongtao
He, Xue
Wang, Li
Yuan, Dongya
He, Yongjun
Jin, Tianbo
He, Shumei
author_facet Hu, Baoping
Wang, Yuhe
Wang, Zhongtao
He, Xue
Wang, Li
Yuan, Dongya
He, Yongjun
Jin, Tianbo
He, Shumei
author_sort Hu, Baoping
collection PubMed
description Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorphisms in or near the SLC11A1 gene and susceptibility to TB. The Agena MassARRAY platform was conducted for genotyping from 510 TB patients and 508 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through logistic regression adjustment age and gender to assess the relationships between polymorphisms and TB risk. Our results identified that rs7608307 was related to increased TB risk in males (CT vs. CC: OR = 1.69, 95%CI: 1.12–2.56, p = 0.013; CT-TT vs. CC: OR = 1.61, 95%CI: 1.08–2.41, p = 0.020) and age ≤41 group (CT vs. CC: OR = 1.66, 95%CI: 1.04–2.65, p = 0.035), respectively. The SNP rs13062 was associated with the TB risk both in males (p = 0.012) and age >41 group (p = 0.021). In addition, we observed that the CC genotype of rs4674301 was correlated with increased TB risk in females (p = 0.043). Our results demonstrated the relationships between polymorphisms (rs7608307, rs4674301, and rs13062) in or near the SLC11A1 gene and age- and sex-specific TB risk in the northwest Chinese Han population.
format Online
Article
Text
id pubmed-9352942
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93529422022-08-06 Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population Hu, Baoping Wang, Yuhe Wang, Zhongtao He, Xue Wang, Li Yuan, Dongya He, Yongjun Jin, Tianbo He, Shumei Front Genet Genetics Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study aimed to investigate the relationships between five polymorphisms in or near the SLC11A1 gene and susceptibility to TB. The Agena MassARRAY platform was conducted for genotyping from 510 TB patients and 508 healthy controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were analyzed through logistic regression adjustment age and gender to assess the relationships between polymorphisms and TB risk. Our results identified that rs7608307 was related to increased TB risk in males (CT vs. CC: OR = 1.69, 95%CI: 1.12–2.56, p = 0.013; CT-TT vs. CC: OR = 1.61, 95%CI: 1.08–2.41, p = 0.020) and age ≤41 group (CT vs. CC: OR = 1.66, 95%CI: 1.04–2.65, p = 0.035), respectively. The SNP rs13062 was associated with the TB risk both in males (p = 0.012) and age >41 group (p = 0.021). In addition, we observed that the CC genotype of rs4674301 was correlated with increased TB risk in females (p = 0.043). Our results demonstrated the relationships between polymorphisms (rs7608307, rs4674301, and rs13062) in or near the SLC11A1 gene and age- and sex-specific TB risk in the northwest Chinese Han population. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9352942/ /pubmed/35938025 http://dx.doi.org/10.3389/fgene.2022.899124 Text en Copyright © 2022 Hu, Wang, Wang, He, Wang, Yuan, He, Jin and He. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Hu, Baoping
Wang, Yuhe
Wang, Zhongtao
He, Xue
Wang, Li
Yuan, Dongya
He, Yongjun
Jin, Tianbo
He, Shumei
Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
title Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
title_full Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
title_fullStr Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
title_full_unstemmed Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
title_short Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population
title_sort association of slc11a1 polymorphisms with tuberculosis susceptibility in the chinese han population
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9352942/
https://www.ncbi.nlm.nih.gov/pubmed/35938025
http://dx.doi.org/10.3389/fgene.2022.899124
work_keys_str_mv AT hubaoping associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT wangyuhe associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT wangzhongtao associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT hexue associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT wangli associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT yuandongya associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT heyongjun associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT jintianbo associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation
AT heshumei associationofslc11a1polymorphismswithtuberculosissusceptibilityinthechinesehanpopulation