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The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes
Autoimmunity involves a loss of immune tolerance to self-proteins due to a combination of genetic susceptibility and environmental provocation, which generates autoreactive T and B cells. Genetic susceptibility affects lymphocyte autoreactivity at the level of central tolerance (e.g., defective, or...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353112/ https://www.ncbi.nlm.nih.gov/pubmed/35935980 http://dx.doi.org/10.3389/fimmu.2022.918837 |