Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir

Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore...

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Autores principales: Lasagna, Angioletta, Piralla, Antonio, Secondino, Simona, Sacchi, Paolo, Baldanti, Fausto, Bruno, Raffaele, Pedrazzoli, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353116/
https://www.ncbi.nlm.nih.gov/pubmed/35935759
http://dx.doi.org/10.3389/fmed.2022.944855
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author Lasagna, Angioletta
Piralla, Antonio
Secondino, Simona
Sacchi, Paolo
Baldanti, Fausto
Bruno, Raffaele
Pedrazzoli, Paolo
author_facet Lasagna, Angioletta
Piralla, Antonio
Secondino, Simona
Sacchi, Paolo
Baldanti, Fausto
Bruno, Raffaele
Pedrazzoli, Paolo
author_sort Lasagna, Angioletta
collection PubMed
description Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore, we present the case of a 22-year-old man with relapsed testicular non-seminomatous germ-cell tumor who was diagnosed with COVID-19 during his first auto-HSCT. Our case report is the first one describing the efficacy of early RDV (and its anti-inflammatory effects that might counterbalance the negative effect of the recombinant human granulocyte-colony stimulating factors -rhG-CSF-) in the context of severe neutropenia following HSCT with the concomitant onset of COVID-19.
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spelling pubmed-93531162022-08-06 Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir Lasagna, Angioletta Piralla, Antonio Secondino, Simona Sacchi, Paolo Baldanti, Fausto Bruno, Raffaele Pedrazzoli, Paolo Front Med (Lausanne) Medicine Coronavirus disease (COVID-19) in patients undergoing hematopoietic stem cell transplantation (HSCT) is a major issue. None of the published papers have reported data on the outcome of HSCT patients with COVID-19 according to the vaccination status and the short course of remdesivir (RDV). Therefore, we present the case of a 22-year-old man with relapsed testicular non-seminomatous germ-cell tumor who was diagnosed with COVID-19 during his first auto-HSCT. Our case report is the first one describing the efficacy of early RDV (and its anti-inflammatory effects that might counterbalance the negative effect of the recombinant human granulocyte-colony stimulating factors -rhG-CSF-) in the context of severe neutropenia following HSCT with the concomitant onset of COVID-19. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9353116/ /pubmed/35935759 http://dx.doi.org/10.3389/fmed.2022.944855 Text en Copyright © 2022 Lasagna, Piralla, Secondino, Sacchi, Baldanti, Bruno and Pedrazzoli. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Lasagna, Angioletta
Piralla, Antonio
Secondino, Simona
Sacchi, Paolo
Baldanti, Fausto
Bruno, Raffaele
Pedrazzoli, Paolo
Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir
title Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir
title_full Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir
title_fullStr Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir
title_full_unstemmed Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir
title_short Case report: Successful outcome of COVID-19 in the context of autologous hematopoietic stem cell transplantation: The impact of the anti-SARS-CoV-2 vaccine and early remdesivir
title_sort case report: successful outcome of covid-19 in the context of autologous hematopoietic stem cell transplantation: the impact of the anti-sars-cov-2 vaccine and early remdesivir
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353116/
https://www.ncbi.nlm.nih.gov/pubmed/35935759
http://dx.doi.org/10.3389/fmed.2022.944855
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