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The use of traditional Chinese medicines in relieving exercise-induced fatigue

Exercise-induced fatigue is a non-pathological fatigue and indicated by a reduction of muscle performance that is caused by excessive physical activity. It seriously affects the daily lives of people, in particular athletes, military personnel, and manual laborers. In recent years, increasing attent...

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Autores principales: Liu, Yuzhou, Li, Congying, Shen, Xiaofei, Liu, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353218/
https://www.ncbi.nlm.nih.gov/pubmed/35935864
http://dx.doi.org/10.3389/fphar.2022.969827
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author Liu, Yuzhou
Li, Congying
Shen, Xiaofei
Liu, Yue
author_facet Liu, Yuzhou
Li, Congying
Shen, Xiaofei
Liu, Yue
author_sort Liu, Yuzhou
collection PubMed
description Exercise-induced fatigue is a non-pathological fatigue and indicated by a reduction of muscle performance that is caused by excessive physical activity. It seriously affects the daily lives of people, in particular athletes, military personnel, and manual laborers. In recent years, increasing attention has been paid to improving the adverse effect of exercise-induced fatigue on people’s daily activities. Thus, studies and applications of traditional Chinese medicines (TCMs) in relieving exercise-induced fatigue have become the focus because of their good curative effects with fewer side effects. This review aims to document and summarize the critical and comprehensive information about the biological processes of exercise-induced fatigue, and to know the types of TCMs, their active components, and possible molecular mechanisms in alleviating exercise-induced fatigue. The peripheral and central mechanisms that cause exercise-induced fatigue have been summarized. A total of 47 exercise-induced fatigue relief TCMs have been collected, mostly including the types of visceral function regulation and emotional adjustment TCMs. Polysaccharides, terpenes, flavonoids/polyphenols are demonstrated to be the major bioactive components. The underlying molecular mechanisms are mainly related to the improvement of energy metabolism, elimination of excess metabolites, inhibition of oxidative stress and inflammatory response, regulation of HPA axis and neurotransmitters. Although current results are obtained mostly from animal models, the clinic trials are still insufficient, and a very few TCMs have been reported to possess potential hepatotoxicity. These findings still offer great reference value, and the significant efficacy in relieving exercise-induced fatigue is impossible to ignore. This review is expected to give insights into the research and development of new TCMs-derived drugs and health care products in relieving exercise-induced fatigue.
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spelling pubmed-93532182022-08-06 The use of traditional Chinese medicines in relieving exercise-induced fatigue Liu, Yuzhou Li, Congying Shen, Xiaofei Liu, Yue Front Pharmacol Pharmacology Exercise-induced fatigue is a non-pathological fatigue and indicated by a reduction of muscle performance that is caused by excessive physical activity. It seriously affects the daily lives of people, in particular athletes, military personnel, and manual laborers. In recent years, increasing attention has been paid to improving the adverse effect of exercise-induced fatigue on people’s daily activities. Thus, studies and applications of traditional Chinese medicines (TCMs) in relieving exercise-induced fatigue have become the focus because of their good curative effects with fewer side effects. This review aims to document and summarize the critical and comprehensive information about the biological processes of exercise-induced fatigue, and to know the types of TCMs, their active components, and possible molecular mechanisms in alleviating exercise-induced fatigue. The peripheral and central mechanisms that cause exercise-induced fatigue have been summarized. A total of 47 exercise-induced fatigue relief TCMs have been collected, mostly including the types of visceral function regulation and emotional adjustment TCMs. Polysaccharides, terpenes, flavonoids/polyphenols are demonstrated to be the major bioactive components. The underlying molecular mechanisms are mainly related to the improvement of energy metabolism, elimination of excess metabolites, inhibition of oxidative stress and inflammatory response, regulation of HPA axis and neurotransmitters. Although current results are obtained mostly from animal models, the clinic trials are still insufficient, and a very few TCMs have been reported to possess potential hepatotoxicity. These findings still offer great reference value, and the significant efficacy in relieving exercise-induced fatigue is impossible to ignore. This review is expected to give insights into the research and development of new TCMs-derived drugs and health care products in relieving exercise-induced fatigue. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9353218/ /pubmed/35935864 http://dx.doi.org/10.3389/fphar.2022.969827 Text en Copyright © 2022 Liu, Li, Shen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Liu, Yuzhou
Li, Congying
Shen, Xiaofei
Liu, Yue
The use of traditional Chinese medicines in relieving exercise-induced fatigue
title The use of traditional Chinese medicines in relieving exercise-induced fatigue
title_full The use of traditional Chinese medicines in relieving exercise-induced fatigue
title_fullStr The use of traditional Chinese medicines in relieving exercise-induced fatigue
title_full_unstemmed The use of traditional Chinese medicines in relieving exercise-induced fatigue
title_short The use of traditional Chinese medicines in relieving exercise-induced fatigue
title_sort use of traditional chinese medicines in relieving exercise-induced fatigue
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353218/
https://www.ncbi.nlm.nih.gov/pubmed/35935864
http://dx.doi.org/10.3389/fphar.2022.969827
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