Cargando…

Shikonin inhibits the proliferation of cervical cancer cells via FAK/AKT/GSK3β signalling

Cervical cancer is one of the most lethal malignancies of the female reproductive system. Shikonin, a naphthoquinone pigment extracted from the traditional medicinal herb, Lithospermum erythrorhizon, has been demonstrated to exert significant inhibitory effects on a variety of tumours in vitro and i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Ziyan, Huang, Liru, Zhang, Tiantian, Liu, Yuwei, Fang, Fang, Wu, Xinyue, Chen, Wen, Lan, Lingning, Zhang, Yangbo, Li, Na, Hu, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353239/ https://www.ncbi.nlm.nih.gov/pubmed/35949620 http://dx.doi.org/10.3892/ol.2022.13424

Ejemplares similares

Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling
por: Li, Huachao, et al.
Publicado: (2018)

Correction: Li et al. Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling. Molecules 2019, 24, 110
por: Li, Huachao, et al.
Publicado: (2023)

Shikonin induces apoptosis and inhibits migration of ovarian carcinoma cells by inhibiting the phosphorylation of Src and FAK
por: HAO, ZHENFENG, et al.
Publicado: (2015)

β-hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: LU, DAN, et al.
Publicado: (2015)

β-Hydroxyisovaleryl-shikonin induces human cervical cancer cell apoptosis via PI3K/AKT/mTOR signaling
por: Lu, Dan, et al.
Publicado: (2021)

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β
por: Gao, Chenxi, et al.
Publicado: (2015)

The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3β pathway and β-catenin stability
por: Benelli, Roberto, et al.
Publicado: (2010)

CHN1 promotes epithelial–mesenchymal transition via the Akt/GSK-3β/Snail pathway in cervical carcinoma
por: Zhao, Haoqi, et al.
Publicado: (2021)

Chrysomycin A Regulates Proliferation and Apoptosis of Neuroglioma Cells via the Akt/GSK-3β Signaling Pathway In Vivo and In Vitro
por: Liu, Dong-Ni, et al.
Publicado: (2023)

EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway
por: Xu, Jian, et al.
Publicado: (2021)

AKT/GSK3β Signaling in Glioblastoma
por: Majewska, Ewelina, et al.
Publicado: (2016)

Acute Ethanol Inhibition of γ Oscillations Is Mediated by Akt and GSK3β
por: Wang, JianGang, et al.
Publicado: (2016)

SDF-1/CXCR4 axis induces human dental pulp stem cell migration through FAK/PI3K/Akt and GSK3β/β-catenin pathways
por: Li, Mingwei, et al.
Publicado: (2017)

Metformin Inhibit Cervical Cancer Migration by Suppressing the FAK/Akt Signaling Pathway
por: Hakimee, Henna, et al.
Publicado: (2019)

Suppressing Cdk5 Activity by Luteolin Inhibits MPP(+)-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways
por: Reudhabibadh, Ratchaneekorn, et al.
Publicado: (2021)

Shikonin Suppresses Skin Carcinogenesis via Inhibiting Cell Proliferation
por: Li, Wenjuan, et al.
Publicado: (2015)

Funky FAK proliferation
por: Tuma, Rabiya S.
Publicado: (2006)

Nobiletin suppresses cholangiocarcinoma proliferation via inhibiting GSK3β
por: You, Liping, et al.
Publicado: (2022)

GSK3β inhibition blocks melanoma cell/host interactions by downregulating N-cadherin expression and decreasing FAK phosphorylation
por: John, Jobin K., et al.
Publicado: (2012)

β-Hydroxyisovaleryl-Shikonin Exerts an Antitumor Effect on Pancreatic Cancer Through the PI3K/AKT Signaling Pathway
por: Zeng, Yu, et al.
Publicado: (2022)

The HSP90 Inhibitor, 17-AAG, Influences the Activation and Proliferation of T Lymphocytes via AKT/GSK3β Signaling in MRL/lpr Mice
por: Hong, Liang-Jian, et al.
Publicado: (2020)

Downregulation of OSR1 Promotes Colon Adenocarcinoma Progression via FAK-Mediated Akt and MAPK Signaling
por: Zhang, Fang, et al.
Publicado: (2020)

Baicalein Inhibits the Proliferation of Cervical Cancer Cells Through the GSK3β-Dependent Pathway
por: Wu, Xiaoling, et al.
Publicado: (2018)

EFNA4 promotes cell proliferation and tumor metastasis in hepatocellular carcinoma through a PIK3R2/GSK3β/β-catenin positive feedback loop
por: Lin, Junhao, et al.
Publicado: (2021)

The potential dual effects of sevoflurane on AKT/GSK3β signaling pathway
por: Zhang, Lei, et al.
Publicado: (2014)

Shikonin induces apoptosis of HaCaT cells via the mitochondrial, Erk and Akt pathways
por: JING, HUILING, et al.
Publicado: (2016)

LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling
por: Qiu, Yan-Song, et al.
Publicado: (2018)

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
por: Lan, Tian, et al.
Publicado: (2021)

PCDH8 inhibits glioma cell proliferation by negatively regulating the AKT/GSK3β/β-catenin signaling pathway
por: Zong, Zhenkun, et al.
Publicado: (2017)

Glypican 1 promotes proliferation and migration in esophagogastric adenocarcinoma via activating AKT/GSK/β-catenin pathway
por: Pratap, Akshay, et al.
Publicado: (2022)

Shikonin inhibits proliferation and induces apoptosis in glioma cells via downregulation of CD147
por: Guo, Na, et al.
Publicado: (2019)

Yangxin granules alleviate doxorubicin-induced cardiotoxicity by suppressing oxidative stress and apoptosis mediated by AKT/GSK3β/β-catenin signaling
por: Ren, Dezhi, et al.
Publicado: (2020)

HMGA1 participates in MHCC97H cell proliferation and invasion through the ILK/Akt/GSK3β signaling pathway
por: Liu, Li, et al.
Publicado: (2017)

Upregulated IQUB promotes cell proliferation and migration via activating Akt/GSK3β/β‐catenin signaling pathway in breast cancer
por: Li, Kai, et al.
Publicado: (2018)

ZNF259 inhibits non-small cell lung cancer cells proliferation and invasion by FAK-AKT signaling
por: Shan, Yuemei, et al.
Publicado: (2017)

UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway
por: Hu, Wei, et al.
Publicado: (2016)

TRPM4 regulates Akt/GSK3‐β activity and enhances β‐catenin signaling and cell proliferation in prostate cancer cells
por: Sagredo, Alfredo I., et al.
Publicado: (2017)

Casein Kinase 2 Interacting Protein-1 Suppresses Glioma Cell Proliferation via Regulating the AKT/GSK3β/β-Catenin Pathway
por: Xi, Yan-Guo, et al.
Publicado: (2019)

Different expression of GSK3β and pS9GSK3β depending on phenotype of cervical cancer: possible association of GSK3β with squamous cell carcinoma and pS9GSK3β with adenocarcinoma
por: Ahn, Kwanghee, et al.
Publicado: (2019)

Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes
por: Wei, Yao, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_uch9upc4s6lhhhlntuc230oohn