Characterization of the immune cell infiltration landscape in myxofibrosarcoma to aid immunotherapy

Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B...

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Detalles Bibliográficos
Autores principales: Zhao, Zi-Yue, Chen, Zhuo-Yuan, Yu, Bin, Xiao, Bo, Liu, Li-Yan, Xia, Yu, Li, Ao-Yu, Wang, Ping-Xiao, Xiang, Cheng, Liu, Chao, Yang, Hui-Qin, Li, Hui, Xiao, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353264/
https://www.ncbi.nlm.nih.gov/pubmed/35936000
http://dx.doi.org/10.3389/fimmu.2022.916915
Descripción
Sumario:Myxofibrosarcoma (MFS) is a highly malignant subtype of soft tissue sarcoma, accounting for 5% of cases. Immunotherapy guided by immune cell infiltration (ICI) is reportedly a promising treatment strategy. Here, MFS samples (n = 104) from two independent databases were classified as ICI clusters A/B/C and gene clusters A/B/C. Then, a close relationship between ICI and gene clusters was established. We found that the features of these clusters were consistent with the characteristics of immune-inflamed tumors (cluster C), immune-desert tumors (cluster B), and immune-excluded tumors (cluster A). Moreover, cluster C was sensitive to immunotherapy. Finally, an independent ICI score was established to predict the therapeutic effect, which has prospects for application in guiding immunotherapy during clinical practice.

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