Cargando…
Research progress on the proteins involved in African swine fever virus infection and replication
African swine fever (ASF) is an acute, hemorrhagic and highly contagious infectious disease caused by African swine fever virus (ASFV), which infects domestic pigs or wild boars. It is characterized by short course of disease, high fever and hemorrhagic lesions, with mortality of up to 100% from acu...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353306/ https://www.ncbi.nlm.nih.gov/pubmed/35935977 http://dx.doi.org/10.3389/fimmu.2022.947180 |
_version_ | 1784762843538653184 |
---|---|
author | Duan, Xianghan Ru, Yi Yang, Wenping Ren, Jingjing Hao, Rongzeng Qin, Xiaodong Li, Dan Zheng, Haixue |
author_facet | Duan, Xianghan Ru, Yi Yang, Wenping Ren, Jingjing Hao, Rongzeng Qin, Xiaodong Li, Dan Zheng, Haixue |
author_sort | Duan, Xianghan |
collection | PubMed |
description | African swine fever (ASF) is an acute, hemorrhagic and highly contagious infectious disease caused by African swine fever virus (ASFV), which infects domestic pigs or wild boars. It is characterized by short course of disease, high fever and hemorrhagic lesions, with mortality of up to 100% from acute infection. Up to now, the lack of commercial vaccines and effective drugs has seriously threatened the healthy economic development of the global pig industry. ASFV is a double-stranded DNA virus and genome varies between about 170-194 kb, which encodes 150-200 viral proteins, including 68 structural proteins and more than 100 non-structural proteins. In recent years, although the research on structure and function of ASFV-encoded proteins has been deepened, the structure and infection process of ASFV are still not clear. This review summarizes the main process of ASFV infection, replication and functions of related viral proteins to provide scientific basis and theoretical basis for ASFV research and vaccine development. |
format | Online Article Text |
id | pubmed-9353306 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93533062022-08-06 Research progress on the proteins involved in African swine fever virus infection and replication Duan, Xianghan Ru, Yi Yang, Wenping Ren, Jingjing Hao, Rongzeng Qin, Xiaodong Li, Dan Zheng, Haixue Front Immunol Immunology African swine fever (ASF) is an acute, hemorrhagic and highly contagious infectious disease caused by African swine fever virus (ASFV), which infects domestic pigs or wild boars. It is characterized by short course of disease, high fever and hemorrhagic lesions, with mortality of up to 100% from acute infection. Up to now, the lack of commercial vaccines and effective drugs has seriously threatened the healthy economic development of the global pig industry. ASFV is a double-stranded DNA virus and genome varies between about 170-194 kb, which encodes 150-200 viral proteins, including 68 structural proteins and more than 100 non-structural proteins. In recent years, although the research on structure and function of ASFV-encoded proteins has been deepened, the structure and infection process of ASFV are still not clear. This review summarizes the main process of ASFV infection, replication and functions of related viral proteins to provide scientific basis and theoretical basis for ASFV research and vaccine development. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9353306/ /pubmed/35935977 http://dx.doi.org/10.3389/fimmu.2022.947180 Text en Copyright © 2022 Duan, Ru, Yang, Ren, Hao, Qin, Li and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author (s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Duan, Xianghan Ru, Yi Yang, Wenping Ren, Jingjing Hao, Rongzeng Qin, Xiaodong Li, Dan Zheng, Haixue Research progress on the proteins involved in African swine fever virus infection and replication |
title | Research progress on the proteins involved in African swine fever virus infection and replication |
title_full | Research progress on the proteins involved in African swine fever virus infection and replication |
title_fullStr | Research progress on the proteins involved in African swine fever virus infection and replication |
title_full_unstemmed | Research progress on the proteins involved in African swine fever virus infection and replication |
title_short | Research progress on the proteins involved in African swine fever virus infection and replication |
title_sort | research progress on the proteins involved in african swine fever virus infection and replication |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353306/ https://www.ncbi.nlm.nih.gov/pubmed/35935977 http://dx.doi.org/10.3389/fimmu.2022.947180 |
work_keys_str_mv | AT duanxianghan researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT ruyi researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT yangwenping researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT renjingjing researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT haorongzeng researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT qinxiaodong researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT lidan researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication AT zhenghaixue researchprogressontheproteinsinvolvedinafricanswinefevervirusinfectionandreplication |