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Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis
Adenomyosis is a common benign uterine lesion that is associated with female infertility, reduced clinical pregnancy rate and high miscarriage risk. While it has been known that the impaired endometrial receptivity is implicated in infertility in patients with adenomyosis, the underlying mechanism r...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353328/ https://www.ncbi.nlm.nih.gov/pubmed/35937844 http://dx.doi.org/10.3389/fendo.2022.928024 |
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author | He, Bin Teng, Xiao-Ming Hao, Fan Zhao, Mei Chen, Zhi-Qin Li, Kun-Ming Yan, Qiang |
author_facet | He, Bin Teng, Xiao-Ming Hao, Fan Zhao, Mei Chen, Zhi-Qin Li, Kun-Ming Yan, Qiang |
author_sort | He, Bin |
collection | PubMed |
description | Adenomyosis is a common benign uterine lesion that is associated with female infertility, reduced clinical pregnancy rate and high miscarriage risk. While it has been known that the impaired endometrial receptivity is implicated in infertility in patients with adenomyosis, the underlying mechanism remains unclear. In the present study, we showed that intracellular protein level of IL-33 was downregulated in the endometrium of patients with adenomyosis, and IL-33 expression status was shown to be positively correlated with that of HOXA10, an endometrial receptivity marker. The subsequent analysis indicated IL-33 overexpression led to the increase of HOXA10 expression and enhancement of embryo implantation in vitro, which was accompanied with induction of STAT3 phosphorylation. Meanwhile, cryptotanshinone, a potent STAT3 inhibitor, was found to significantly suppress the increase of HOXA10 expression and embryo implantation caused by IL-33 overexpression in vitro, revealing the critical role of STAT3 activity. Consistently, the positive relationship between IL33 and HOXA10 expression in the endometrium was verified in the analysis of adenomyosis mouse model. |
format | Online Article Text |
id | pubmed-9353328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93533282022-08-06 Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis He, Bin Teng, Xiao-Ming Hao, Fan Zhao, Mei Chen, Zhi-Qin Li, Kun-Ming Yan, Qiang Front Endocrinol (Lausanne) Endocrinology Adenomyosis is a common benign uterine lesion that is associated with female infertility, reduced clinical pregnancy rate and high miscarriage risk. While it has been known that the impaired endometrial receptivity is implicated in infertility in patients with adenomyosis, the underlying mechanism remains unclear. In the present study, we showed that intracellular protein level of IL-33 was downregulated in the endometrium of patients with adenomyosis, and IL-33 expression status was shown to be positively correlated with that of HOXA10, an endometrial receptivity marker. The subsequent analysis indicated IL-33 overexpression led to the increase of HOXA10 expression and enhancement of embryo implantation in vitro, which was accompanied with induction of STAT3 phosphorylation. Meanwhile, cryptotanshinone, a potent STAT3 inhibitor, was found to significantly suppress the increase of HOXA10 expression and embryo implantation caused by IL-33 overexpression in vitro, revealing the critical role of STAT3 activity. Consistently, the positive relationship between IL33 and HOXA10 expression in the endometrium was verified in the analysis of adenomyosis mouse model. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9353328/ /pubmed/35937844 http://dx.doi.org/10.3389/fendo.2022.928024 Text en Copyright © 2022 He, Teng, Hao, Zhao, Chen, Li and Yan https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Endocrinology He, Bin Teng, Xiao-Ming Hao, Fan Zhao, Mei Chen, Zhi-Qin Li, Kun-Ming Yan, Qiang Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis |
title | Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis |
title_full | Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis |
title_fullStr | Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis |
title_full_unstemmed | Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis |
title_short | Decreased intracellular IL-33 impairs endometrial receptivity in women with adenomyosis |
title_sort | decreased intracellular il-33 impairs endometrial receptivity in women with adenomyosis |
topic | Endocrinology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353328/ https://www.ncbi.nlm.nih.gov/pubmed/35937844 http://dx.doi.org/10.3389/fendo.2022.928024 |
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