Protein Scaffold‐Based Multimerization of Soluble ACE2 Efficiently Blocks SARS‐CoV‐2 Infection In Vitro and In Vivo

Soluble ACE2 (sACE2) decoys are promising agents to inhibit SARS‐CoV‐2, as their efficiency is unlikely to be affected by escape mutations. However, their success is limited by their relatively poor potency. To address this challenge, multimeric sACE2 consisting of SunTag or MoonTag systems is devel...

Descripción completa

Detalles Bibliográficos
Autores principales: Kayabolen, Alisan, Akcan, Ugur, Özturan, Doğancan, Ulbegi‐Polat, Hivda, Sahin, Gizem Nur, Pinarbasi‐Degirmenci, Nareg, Bayraktar, Canan, Soyler, Gizem, Sarayloo, Ehsan, Nurtop, Elif, Ozer, Berna, Guney‐Esken, Gulen, Barlas, Tayfun, Yildirim, Ismail Selim, Dogan, Ozlem, Karahuseyinoglu, Sercin, Lack, Nathan A., Kaya, Mehmet, Albayrak, Cem, Can, Fusun, Solaroglu, Ihsan, Bagci‐Onder, Tugba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353362/
https://www.ncbi.nlm.nih.gov/pubmed/35896894
http://dx.doi.org/10.1002/advs.202201294

Ejemplares similares

Ejemplares similares