A Temporal PROTAC Cocktail‐Mediated Sequential Degradation of AURKA Abrogates Acute Myeloid Leukemia Stem Cells

AURKA is a potential kinase target in various malignancies. The kinase‐independent oncogenic functions partially disclose the inadequate efficacy of the kinase inhibitor in a Phase III clinical trial. Simultaneously targeting the catalytic and noncatalytic functions of AURKA may be a feasible approa...

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Detalles Bibliográficos
Autores principales: Liu, Fang, Wang, Xuan, Duan, Jianli, Hou, Zhijie, Wu, Zhouming, Liu, Lingling, Lei, Hanqi, Huang, Dan, Ren, Yifei, Wang, Yue, Li, Xinyan, Zhuo, Junxiao, Zhang, Zijian, He, Bin, Yan, Min, Yuan, Huiming, Zhang, Lihua, Yan, Jinsong, Wen, Shijun, Wang, Zifeng, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353462/
https://www.ncbi.nlm.nih.gov/pubmed/35652200
http://dx.doi.org/10.1002/advs.202104823

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353462/
https://www.ncbi.nlm.nih.gov/pubmed/35652200
http://dx.doi.org/10.1002/advs.202104823

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