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Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases

One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis. Taking into account the metabolic effects in the patient’s body, tic...

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Autores principales: Groth, Monika, Skrzydlewska, Elżbieta, Dobrzyńska, Marta, Pancewicz, Sławomir, Moniuszko-Malinowska, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353526/
https://www.ncbi.nlm.nih.gov/pubmed/35937690
http://dx.doi.org/10.3389/fcimb.2022.870398
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author Groth, Monika
Skrzydlewska, Elżbieta
Dobrzyńska, Marta
Pancewicz, Sławomir
Moniuszko-Malinowska, Anna
author_facet Groth, Monika
Skrzydlewska, Elżbieta
Dobrzyńska, Marta
Pancewicz, Sławomir
Moniuszko-Malinowska, Anna
author_sort Groth, Monika
collection PubMed
description One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis. Taking into account the metabolic effects in the patient’s body, tick-borne diseases are a significant problem from an epidemiological and clinical point of view. Inflammation and oxidative stress are key elements in the pathogenesis of infectious diseases, including tick-borne diseases. In consequence, this leads to oxidative modifications of the structure and function of phospholipids and proteins and results in qualitative and quantitative changes at the level of lipid mediators arising in both reactive oxygen species (ROS) and ROS enzyme–dependent reactions. These types of metabolic modifications affect the functioning of the cells and the host organism. Therefore, links between the severity of the disease state and redox imbalance and the level of phospholipid metabolites are being searched, hoping to find unambiguous diagnostic biomarkers. Assessment of molecular effects of oxidative stress may also enable the monitoring of the disease process and treatment efficacy.
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spelling pubmed-93535262022-08-06 Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases Groth, Monika Skrzydlewska, Elżbieta Dobrzyńska, Marta Pancewicz, Sławomir Moniuszko-Malinowska, Anna Front Cell Infect Microbiol Cellular and Infection Microbiology One of the growing global health problems are vector-borne diseases, including tick-borne diseases. The most common tick-borne diseases include Lyme disease, tick-borne encephalitis, human granulocytic anaplasmosis, and babesiosis. Taking into account the metabolic effects in the patient’s body, tick-borne diseases are a significant problem from an epidemiological and clinical point of view. Inflammation and oxidative stress are key elements in the pathogenesis of infectious diseases, including tick-borne diseases. In consequence, this leads to oxidative modifications of the structure and function of phospholipids and proteins and results in qualitative and quantitative changes at the level of lipid mediators arising in both reactive oxygen species (ROS) and ROS enzyme–dependent reactions. These types of metabolic modifications affect the functioning of the cells and the host organism. Therefore, links between the severity of the disease state and redox imbalance and the level of phospholipid metabolites are being searched, hoping to find unambiguous diagnostic biomarkers. Assessment of molecular effects of oxidative stress may also enable the monitoring of the disease process and treatment efficacy. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9353526/ /pubmed/35937690 http://dx.doi.org/10.3389/fcimb.2022.870398 Text en Copyright © 2022 Groth, Skrzydlewska, Dobrzyńska, Pancewicz and Moniuszko-Malinowska https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Groth, Monika
Skrzydlewska, Elżbieta
Dobrzyńska, Marta
Pancewicz, Sławomir
Moniuszko-Malinowska, Anna
Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases
title Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases
title_full Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases
title_fullStr Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases
title_full_unstemmed Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases
title_short Redox Imbalance and Its Metabolic Consequences in Tick-Borne Diseases
title_sort redox imbalance and its metabolic consequences in tick-borne diseases
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353526/
https://www.ncbi.nlm.nih.gov/pubmed/35937690
http://dx.doi.org/10.3389/fcimb.2022.870398
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