Cargando…

Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells

Pancreatic beta cell homeostasis is crucial for the synthesis and secretion of insulin; disruption of homeostasis causes diabetes, and is a treatment target. Adaptation to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR) and adequate regulation of autophagy, which are cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Moon, Seoil, Jung, Hye Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353561/
https://www.ncbi.nlm.nih.gov/pubmed/35929171
http://dx.doi.org/10.4093/dmj.2022.0070
_version_ 1784762891327504384
author Moon, Seoil
Jung, Hye Seung
author_facet Moon, Seoil
Jung, Hye Seung
author_sort Moon, Seoil
collection PubMed
description Pancreatic beta cell homeostasis is crucial for the synthesis and secretion of insulin; disruption of homeostasis causes diabetes, and is a treatment target. Adaptation to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR) and adequate regulation of autophagy, which are closely linked, play essential roles in this homeostasis. In diabetes, the UPR and autophagy are dysregulated, which leads to beta cell failure and death. Various studies have explored methods to preserve pancreatic beta cell function and mass by relieving ER stress and regulating autophagic activity. To promote clinical translation of these research results to potential therapeutics for diabetes, we summarize the current knowledge on ER stress and autophagy in human insulin-secreting cells.
format Online
Article
Text
id pubmed-9353561
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Korean Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-93535612022-08-11 Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells Moon, Seoil Jung, Hye Seung Diabetes Metab J Review Pancreatic beta cell homeostasis is crucial for the synthesis and secretion of insulin; disruption of homeostasis causes diabetes, and is a treatment target. Adaptation to endoplasmic reticulum (ER) stress through the unfolded protein response (UPR) and adequate regulation of autophagy, which are closely linked, play essential roles in this homeostasis. In diabetes, the UPR and autophagy are dysregulated, which leads to beta cell failure and death. Various studies have explored methods to preserve pancreatic beta cell function and mass by relieving ER stress and regulating autophagic activity. To promote clinical translation of these research results to potential therapeutics for diabetes, we summarize the current knowledge on ER stress and autophagy in human insulin-secreting cells. Korean Diabetes Association 2022-07 2022-07-27 /pmc/articles/PMC9353561/ /pubmed/35929171 http://dx.doi.org/10.4093/dmj.2022.0070 Text en Copyright © 2022 Korean Diabetes Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Moon, Seoil
Jung, Hye Seung
Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
title Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
title_full Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
title_fullStr Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
title_full_unstemmed Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
title_short Endoplasmic Reticulum Stress and Dysregulated Autophagy in Human Pancreatic Beta Cells
title_sort endoplasmic reticulum stress and dysregulated autophagy in human pancreatic beta cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353561/
https://www.ncbi.nlm.nih.gov/pubmed/35929171
http://dx.doi.org/10.4093/dmj.2022.0070
work_keys_str_mv AT moonseoil endoplasmicreticulumstressanddysregulatedautophagyinhumanpancreaticbetacells
AT junghyeseung endoplasmicreticulumstressanddysregulatedautophagyinhumanpancreaticbetacells