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Reduction of H3K27cr Modification During DNA Damage in Colon Cancer
DNA damage plays an essential role in the initiation and development of colon cancer. Histone crotonylation is a newly discovered post-translational modification that is thought to promote gene expression. Whether histone crotonylation plays a role in DNA damage of cancer remains unknown, as does th...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353715/ https://www.ncbi.nlm.nih.gov/pubmed/35936700 http://dx.doi.org/10.3389/fonc.2022.924061 |
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author | Liao, Meijian Chu, Weiwei Sun, Xiaolin Zheng, Wendan Gao, Shoucui Li, Danhua Pei, Dongsheng |
author_facet | Liao, Meijian Chu, Weiwei Sun, Xiaolin Zheng, Wendan Gao, Shoucui Li, Danhua Pei, Dongsheng |
author_sort | Liao, Meijian |
collection | PubMed |
description | DNA damage plays an essential role in the initiation and development of colon cancer. Histone crotonylation is a newly discovered post-translational modification that is thought to promote gene expression. Whether histone crotonylation plays a role in DNA damage of cancer remains unknown, as does the putative underlying molecular mechanism. This study aimed to investigate the relationship between histone crotonylation and DNA damage of colon cancer using multiple bioinformatics analysis and western blotting. We discovered that genes with promoter occupied by histone crotonylation were associated with the activity of DNA damage in colon cancer patients. Additionally, we uncovered that the level of crotonylation on Lys27 of histone H3 (H3K27cr) decreased during camptothecin and etoposide treatment. Interestingly, sirtuin 6 was found to regulate the cellular level of H3K27cr. Taking these data together, our study provided a new perspective about histone crotonylation and DNA damage in colon cancer. |
format | Online Article Text |
id | pubmed-9353715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93537152022-08-06 Reduction of H3K27cr Modification During DNA Damage in Colon Cancer Liao, Meijian Chu, Weiwei Sun, Xiaolin Zheng, Wendan Gao, Shoucui Li, Danhua Pei, Dongsheng Front Oncol Oncology DNA damage plays an essential role in the initiation and development of colon cancer. Histone crotonylation is a newly discovered post-translational modification that is thought to promote gene expression. Whether histone crotonylation plays a role in DNA damage of cancer remains unknown, as does the putative underlying molecular mechanism. This study aimed to investigate the relationship between histone crotonylation and DNA damage of colon cancer using multiple bioinformatics analysis and western blotting. We discovered that genes with promoter occupied by histone crotonylation were associated with the activity of DNA damage in colon cancer patients. Additionally, we uncovered that the level of crotonylation on Lys27 of histone H3 (H3K27cr) decreased during camptothecin and etoposide treatment. Interestingly, sirtuin 6 was found to regulate the cellular level of H3K27cr. Taking these data together, our study provided a new perspective about histone crotonylation and DNA damage in colon cancer. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9353715/ /pubmed/35936700 http://dx.doi.org/10.3389/fonc.2022.924061 Text en Copyright © 2022 Liao, Chu, Sun, Zheng, Gao, Li and Pei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Liao, Meijian Chu, Weiwei Sun, Xiaolin Zheng, Wendan Gao, Shoucui Li, Danhua Pei, Dongsheng Reduction of H3K27cr Modification During DNA Damage in Colon Cancer |
title | Reduction of H3K27cr Modification During DNA Damage in Colon Cancer |
title_full | Reduction of H3K27cr Modification During DNA Damage in Colon Cancer |
title_fullStr | Reduction of H3K27cr Modification During DNA Damage in Colon Cancer |
title_full_unstemmed | Reduction of H3K27cr Modification During DNA Damage in Colon Cancer |
title_short | Reduction of H3K27cr Modification During DNA Damage in Colon Cancer |
title_sort | reduction of h3k27cr modification during dna damage in colon cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353715/ https://www.ncbi.nlm.nih.gov/pubmed/35936700 http://dx.doi.org/10.3389/fonc.2022.924061 |
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