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Dexmededomidine in pediatric unilateral internal inguinal ring ligation
BACKGROUND: Safe and effective analgesia strategy remains one of the priorities for pediatric inguinal hernia treatment. AIM: To explore safety and efficacy of dexmededomidine monotherapy for postoperative analgesia in children who received laparoscopic unilateral internal inguinal ring ligation. ME...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353900/ https://www.ncbi.nlm.nih.gov/pubmed/36157988 http://dx.doi.org/10.12998/wjcc.v10.i21.7376 |
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author | Liu, Guang Zhang, Ling Wang, Hui-Se Lin, Yi Jin, Hong-Quan Wang, Xiao-Dan Qiao, Wei-Na Zhang, Ya-Tao Sun, Jiao-Qian Liu, Zhi-Na |
author_facet | Liu, Guang Zhang, Ling Wang, Hui-Se Lin, Yi Jin, Hong-Quan Wang, Xiao-Dan Qiao, Wei-Na Zhang, Ya-Tao Sun, Jiao-Qian Liu, Zhi-Na |
author_sort | Liu, Guang |
collection | PubMed |
description | BACKGROUND: Safe and effective analgesia strategy remains one of the priorities for pediatric inguinal hernia treatment. AIM: To explore safety and efficacy of dexmededomidine monotherapy for postoperative analgesia in children who received laparoscopic unilateral internal inguinal ring ligation. METHODS: This randomized single-center controlled trial included 390 children (aged 1-3 years, ASA grade I-II), randomly divided into a dexmededomidine group (D group), a dexmededomidine + sufentanil group (DS group), and a sufentanil group (S group). The primary endpoint was percentage of children with the Face, Legs, Activity, Cry, and Consolability (FLACC) score ≤ 3 points 2 h after surgery. RESULTS: The comparisons of the FLACC scores at 2, 4, 6, 8, 12, and 24 h were not significantly different among the three groups (P > 0.05). The sedative effects in the D group were significantly better than those in the S group (P > 0.05), but not significantly different from those in the DS group. The incidence of nausea and vomiting was significantly lower in the D group than in the S group and DS group (P > 0.05). CONCLUSION: Analgesic effects of dexmededomidine monotherapy are comparable to those of sufentanil alone or in combination with dexmededomidine for children who underwent laparoscopic unilateral internal inguinal ring ligation, with better sedative effects and a lower incidence of adverse events. |
format | Online Article Text |
id | pubmed-9353900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-93539002022-09-23 Dexmededomidine in pediatric unilateral internal inguinal ring ligation Liu, Guang Zhang, Ling Wang, Hui-Se Lin, Yi Jin, Hong-Quan Wang, Xiao-Dan Qiao, Wei-Na Zhang, Ya-Tao Sun, Jiao-Qian Liu, Zhi-Na World J Clin Cases Randomized Clinical Trial BACKGROUND: Safe and effective analgesia strategy remains one of the priorities for pediatric inguinal hernia treatment. AIM: To explore safety and efficacy of dexmededomidine monotherapy for postoperative analgesia in children who received laparoscopic unilateral internal inguinal ring ligation. METHODS: This randomized single-center controlled trial included 390 children (aged 1-3 years, ASA grade I-II), randomly divided into a dexmededomidine group (D group), a dexmededomidine + sufentanil group (DS group), and a sufentanil group (S group). The primary endpoint was percentage of children with the Face, Legs, Activity, Cry, and Consolability (FLACC) score ≤ 3 points 2 h after surgery. RESULTS: The comparisons of the FLACC scores at 2, 4, 6, 8, 12, and 24 h were not significantly different among the three groups (P > 0.05). The sedative effects in the D group were significantly better than those in the S group (P > 0.05), but not significantly different from those in the DS group. The incidence of nausea and vomiting was significantly lower in the D group than in the S group and DS group (P > 0.05). CONCLUSION: Analgesic effects of dexmededomidine monotherapy are comparable to those of sufentanil alone or in combination with dexmededomidine for children who underwent laparoscopic unilateral internal inguinal ring ligation, with better sedative effects and a lower incidence of adverse events. Baishideng Publishing Group Inc 2022-07-26 2022-07-26 /pmc/articles/PMC9353900/ /pubmed/36157988 http://dx.doi.org/10.12998/wjcc.v10.i21.7376 Text en ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Randomized Clinical Trial Liu, Guang Zhang, Ling Wang, Hui-Se Lin, Yi Jin, Hong-Quan Wang, Xiao-Dan Qiao, Wei-Na Zhang, Ya-Tao Sun, Jiao-Qian Liu, Zhi-Na Dexmededomidine in pediatric unilateral internal inguinal ring ligation |
title | Dexmededomidine in pediatric unilateral internal inguinal ring ligation |
title_full | Dexmededomidine in pediatric unilateral internal inguinal ring ligation |
title_fullStr | Dexmededomidine in pediatric unilateral internal inguinal ring ligation |
title_full_unstemmed | Dexmededomidine in pediatric unilateral internal inguinal ring ligation |
title_short | Dexmededomidine in pediatric unilateral internal inguinal ring ligation |
title_sort | dexmededomidine in pediatric unilateral internal inguinal ring ligation |
topic | Randomized Clinical Trial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9353900/ https://www.ncbi.nlm.nih.gov/pubmed/36157988 http://dx.doi.org/10.12998/wjcc.v10.i21.7376 |
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