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Discovery of BRAF/HDAC Dual Inhibitors Suppressing Proliferation of Human Colorectal Cancer Cells
The combination of histone deacetylase inhibitor and BRAF inhibitor (BRAFi) has been shown to enhance the antineoplastic effect and reduce the progress of BRAFi resistance. In this study, a series of (thiazol-5-yl)pyrimidin-2-yl)amino)-N-hydroxyalkanamide derivatives were designed and synthesized as...
Autores principales: | Li, Yingjun, Huang, Yongjun, Cheng, Huimin, Xu, Fang, Qi, Ruxi, Dai, Botao, Yang, Yujian, Tu, Zhengchao, Peng, Lijie, Zhang, Zhang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354042/ https://www.ncbi.nlm.nih.gov/pubmed/35936102 http://dx.doi.org/10.3389/fchem.2022.910353 |
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