Riluzole–Rasagiline Hybrids: Toward the Development of Multi-Target-Directed Ligands for Amyotrophic Lateral Sclerosis

[Image: see text] Polypharmacology is a new trend in amyotrophic lateral sclerosis (ALS) therapy and an effective way of addressing a multifactorial etiology involving excitotoxicity, mitochondrial dysfunction, oxidative stress, and microglial activation. Inspired by a reported clinical trial, we co...

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Detalles Bibliográficos
Autores principales: Albertini, Claudia, Salerno, Alessandra, Atzeni, Silvia, Uliassi, Elisa, Massenzio, Francesca, Maruca, Annalisa, Rocca, Roberta, Mecava, Marko, Silva, Filomena S. G., Mena, Débora, Valente, Pedro, Duarte, Ana I., Chavarria, Daniel, Bissaro, Maicol, Moro, Stefano, Federico, Stephanie, Spalluto, Giampiero, Soukup, Ondřej, Borges, Fernanda, Alcaro, Stefano, Monti, Barbara, Oliveira, Paulo J., Menéndez, Josè C., Bolognesi, Maria Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354084/
https://www.ncbi.nlm.nih.gov/pubmed/35868251
http://dx.doi.org/10.1021/acschemneuro.2c00261

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