Programmable Attenuation of Antigenic Sensitivity for a Nanobody-Based EGFR Chimeric Antigen Receptor Through Hinge Domain Truncation

Epidermal growth factor family receptor (EGFR) is commonly overexpressed in many solid tumors and an attractive target for chimeric antigen receptor (CAR)-T therapy, but as EGFR is also expressed at lower levels in healthy tissues a therapeutic strategy must balance antigenic responsiveness against...

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Detalles Bibliográficos
Autores principales: McComb, Scott, Nguyen, Tina, Shepherd, Alex, Henry, Kevin A., Bloemberg, Darin, Marcil, Anne, Maclean, Susanne, Zafer, Ahmed, Gilbert, Rénald, Gadoury, Christine, Pon, Robert A., Sulea, Traian, Zhu, Qin, Weeratna, Risini D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354126/
https://www.ncbi.nlm.nih.gov/pubmed/35935988
http://dx.doi.org/10.3389/fimmu.2022.864868

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