MMAP-05 PHASE I STUDY OF CONCURRENT PAXALISIB AND RADIATION THERAPY IN PATIENTS WITH SOLID TUMOR BRAIN METASTASES OR LEPTOMENINGEAL METASTASES HARBORING PI3K PATHWAY MUTATIONS: RESULTS FROM THE DOSE-ESCALATION COHORT

INTRODUCTION: Radiation therapy (RT) is an effective treatment for patients with central nervous system metastases, but disease control is poor in patients with tumors that harbor PI3K pathway alterations. We hypothesized that combining RT with paxalisib, a CNS-penetrant small molecule PI3K/mTOR inh...

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Detalles Bibliográficos
Autores principales: Yang, Jonathan, Mann, Justin, Pike, Luke, Zinovoy, Melissa, Young, Robert, Offin, Michael, Mitchell, Ryan, Kazarian, Arousiak, Shadat, Tamim, Garner, James, Simpson, Jeremy, Friend, John, Gavrilovic, Igor, Piotrowski, Anna, Wilcox, Jessica, Malani, Rachna, Diamond, Eli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354144/
http://dx.doi.org/10.1093/noajnl/vdac078.061

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