CLRM-08 TARGETING IMMUNE-PAYLOAD TO THE GLIOBLASTOMA TUMOR MICROENVIRONMENT USING A MACROPHAGE-BASED TREATMENT RELYING ON AUTOLOGOUS, GENETICALLY MODIFIED, HEMATOPOIETIC STEM CELL-BASED THERAPY: THE TEM-GBM STUDY (NCT03866109)

We developed an autologous hematopoietic stem cell-based platform designed to deliver IFNa, by a transcriptional and post-transcriptional control mechanism mediated by miRNA target sequences, specifically into the tumor microenvironment (TME) via Tie-2 expressing monocytes (Temferon). As of Feb 2022...

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Detalles Bibliográficos
Autores principales: Eoli, Marica, Farina, Francesca, Gentner, Bernhard, Capotondo, Alessia, Anghileri, Elena, Barcella, Matteo, Brambilla, Valentina, Bruzzone, Maria Grazia, Carrabba, Matteo, Cuccarini, Valeria, d’Alessandris, Giorgio, Meco, Francesco Di, Ferla, Valeria, Franzin, Alberto, Ferroli, Paolo, Gagliardi, Filippo, Legnani, Federico, Mazzoleni, Stefania, Mortini, Pietro, Naldini, Matteo Maria, Olivi, Alessandro, Pallini, Roberto, Patanè, Monica, Paterra, Rosina, Pollo, Bianca, Saini, Massimo, Snider, Silvia, Naldini, Luigi, Russo, Carlo, Finocchiaro, Gaetano, Ciceri, Fabio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354155/
http://dx.doi.org/10.1093/noajnl/vdac078.028

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