SPCR-03 NEUROCOGNITIVE OUTCOMES FROM PHASE 1 TRIAL OF BMX-001 IN COMBINATION WITH CONCURRENT RADIATION THERAPY AND TEMOZOLOMIDE IN NEWLY DIAGNOSED HIGH-GRADE GLIOMA PATIENTS

INTRODUCTION: Neurocognitive dysfunction can result from radiation therapy which is the mainstay of treatment for high-grade glioma, particularly glioblastoma. Preclinical observations found that BMX-001, a novel metalloporphyrin, acts as a radioprotectant for normal CNS cells yet as a radiosensitiz...

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Detalles Bibliográficos
Autores principales: Peters, Katherine, Kirkpatrick, John, Batinic-Haberle, Ines, Affronti, Mary Lou, Woodring, Sarah, Lipp, Eric, Herndon, James, Boyd, Kendra, Spasojevic, Ivan, Penchev, Sara, Gad, Shayne, Silberstein, David, Johnson, Margaret, Desjardins, Annick, Friedman, Henry, Ashley, David, Crapo, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354202/
http://dx.doi.org/10.1093/noajnl/vdac078.078

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