BSCI-20 STING EPIGENETIC SILENCING IN GLIOMAS CAN BE RESCUED BY METHYLTRANSFERASE INHIBITION: IMPLICATIONS FOR NOVEL THERAPEUTIC APPROACHES

The stimulator of interferon genes (STING) is a key component of the innate immune response to pathogenic cytosolic DNA, resulting in IRF3- and NFκB-dependent transcription of type I interferons (IFN) and pro-inflammatory cytokines. STING activation primes endogenous antitumor immunity and is disrup...

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Detalles Bibliográficos
Autores principales: Low, Justin, Chandramohan, Vidya, Bowie, Michelle, Brown, Michael, Waitkus, Matthew, Briley, Aaron, Stevenson, Kevin, Fuller, Rebecca, Hostettler, Janell, Reitman, Zachary, Charbonneau, Casey, Keir, Stephen, Khasraw, Mustafa, Ashley, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Supplement Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354204/
http://dx.doi.org/10.1093/noajnl/vdac078.018

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