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Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study
BACKGROUND: Delayed cord clamping increases placental transfusion. In vaginal deliveries higher hemoglobin concentrations are found in the second-born twin. We hypothesized it is unrelated to intertwin transfusion but to the time of cord clamping. Methods: It was a prospective cohort study of 202 wo...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354348/ https://www.ncbi.nlm.nih.gov/pubmed/35931974 http://dx.doi.org/10.1186/s12884-022-04942-2 |
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author | Kosińska-Kaczyńska, Katarzyna Witwicki, Jacek Saletra-Bielińska, Aleksandra Krajewski, Paweł Krysiak, Adam Brawura-Biskupski-Samaha, Robert Walasik, Izabela Zgliczyńska, Magdalena Malicka, Ewa Szymusik, Iwona |
author_facet | Kosińska-Kaczyńska, Katarzyna Witwicki, Jacek Saletra-Bielińska, Aleksandra Krajewski, Paweł Krysiak, Adam Brawura-Biskupski-Samaha, Robert Walasik, Izabela Zgliczyńska, Magdalena Malicka, Ewa Szymusik, Iwona |
author_sort | Kosińska-Kaczyńska, Katarzyna |
collection | PubMed |
description | BACKGROUND: Delayed cord clamping increases placental transfusion. In vaginal deliveries higher hemoglobin concentrations are found in the second-born twin. We hypothesized it is unrelated to intertwin transfusion but to the time of cord clamping. Methods: It was a prospective cohort study of 202 women delivering twins > 32 weeks of gestation. Monoamniotic pregnancy, antenatal intertwin transfusions, fetal demise or major abnormalities were excluded from the study. The time of cord clamping depended on the obstetrician’s decision. Hemoglobin, hematocrit, and reticulocyte count were measured at birth and during the second day of life. RESULTS: At birth, hemoglobin and hematocrit levels were significantly higher in the first-born twins delivered with delayed than with early cord clamping. Higher hemoglobin and hematocrit levels were observed during the second day of life in all twins delivered with delayed cord clamping. The lowest levels were observed in twins delivered with early cord clamping. Infants delivered with delayed cord clamping were at a lower risk of respiratory disorders and NICU hospitalization. CONCLUSION: The observed differences in Hgb concentrations between the infants in a twin pregnancy are related to cord clamping time. |
format | Online Article Text |
id | pubmed-9354348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-93543482022-08-06 Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study Kosińska-Kaczyńska, Katarzyna Witwicki, Jacek Saletra-Bielińska, Aleksandra Krajewski, Paweł Krysiak, Adam Brawura-Biskupski-Samaha, Robert Walasik, Izabela Zgliczyńska, Magdalena Malicka, Ewa Szymusik, Iwona BMC Pregnancy Childbirth Research BACKGROUND: Delayed cord clamping increases placental transfusion. In vaginal deliveries higher hemoglobin concentrations are found in the second-born twin. We hypothesized it is unrelated to intertwin transfusion but to the time of cord clamping. Methods: It was a prospective cohort study of 202 women delivering twins > 32 weeks of gestation. Monoamniotic pregnancy, antenatal intertwin transfusions, fetal demise or major abnormalities were excluded from the study. The time of cord clamping depended on the obstetrician’s decision. Hemoglobin, hematocrit, and reticulocyte count were measured at birth and during the second day of life. RESULTS: At birth, hemoglobin and hematocrit levels were significantly higher in the first-born twins delivered with delayed than with early cord clamping. Higher hemoglobin and hematocrit levels were observed during the second day of life in all twins delivered with delayed cord clamping. The lowest levels were observed in twins delivered with early cord clamping. Infants delivered with delayed cord clamping were at a lower risk of respiratory disorders and NICU hospitalization. CONCLUSION: The observed differences in Hgb concentrations between the infants in a twin pregnancy are related to cord clamping time. BioMed Central 2022-08-05 /pmc/articles/PMC9354348/ /pubmed/35931974 http://dx.doi.org/10.1186/s12884-022-04942-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Kosińska-Kaczyńska, Katarzyna Witwicki, Jacek Saletra-Bielińska, Aleksandra Krajewski, Paweł Krysiak, Adam Brawura-Biskupski-Samaha, Robert Walasik, Izabela Zgliczyńska, Magdalena Malicka, Ewa Szymusik, Iwona Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
title | Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
title_full | Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
title_fullStr | Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
title_full_unstemmed | Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
title_short | Hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
title_sort | hemoglobin differences in twins are related to the time of cord clamping, not intertwin transfusion – a prospective cohort study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354348/ https://www.ncbi.nlm.nih.gov/pubmed/35931974 http://dx.doi.org/10.1186/s12884-022-04942-2 |
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