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Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure

Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of various comorbidities on HBV-ACLF in a large population. This...

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Autores principales: Weng, Wei-zhen, Chen, Jun-feng, Peng, Xiao-hua, Huang, Miao, Zhang, Jing, Xiong, Jing, Cao, Hui-juan, Lin, Bing-liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354478/
https://www.ncbi.nlm.nih.gov/pubmed/35788251
http://dx.doi.org/10.1017/S0950268822001169
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author Weng, Wei-zhen
Chen, Jun-feng
Peng, Xiao-hua
Huang, Miao
Zhang, Jing
Xiong, Jing
Cao, Hui-juan
Lin, Bing-liang
author_facet Weng, Wei-zhen
Chen, Jun-feng
Peng, Xiao-hua
Huang, Miao
Zhang, Jing
Xiong, Jing
Cao, Hui-juan
Lin, Bing-liang
author_sort Weng, Wei-zhen
collection PubMed
description Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of various comorbidities on HBV-ACLF in a large population. This study aimed to investigate the relationship between comorbidities, complications and mortality. In this retrospective observational study, we identified 2166 cases of HBV-ACLF hospitalised from January 2010 to March 2018. Demographic data from the patients, medical history, treatment, laboratory indices, comorbidities and complications were collected. The mortality rate in our study group was 47.37%. Type 2 diabetes mellitus was the most common comorbidity, followed by alcoholic liver disease. Spontaneous bacterial peritonitis, pneumonia and hepatic encephalopathy (HE) were common in these patients. Diabetes mellitus and hyperthyroidism are risk factors for death within 90 days, together with gastrointestinal bleeding and HE at admission, HE and hepatorenal syndrome during hospitalisation. Knowledge of risk factors can help identify HBV-ACLF patients with a poor prognosis for HBV-ACLF with comorbidities and complications.
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spelling pubmed-93544782022-08-15 Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure Weng, Wei-zhen Chen, Jun-feng Peng, Xiao-hua Huang, Miao Zhang, Jing Xiong, Jing Cao, Hui-juan Lin, Bing-liang Epidemiol Infect Original Paper Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is a severe and life-threatening complication, characterised by multi-organ failure and high short-term mortality. However, there is limited information on the impact of various comorbidities on HBV-ACLF in a large population. This study aimed to investigate the relationship between comorbidities, complications and mortality. In this retrospective observational study, we identified 2166 cases of HBV-ACLF hospitalised from January 2010 to March 2018. Demographic data from the patients, medical history, treatment, laboratory indices, comorbidities and complications were collected. The mortality rate in our study group was 47.37%. Type 2 diabetes mellitus was the most common comorbidity, followed by alcoholic liver disease. Spontaneous bacterial peritonitis, pneumonia and hepatic encephalopathy (HE) were common in these patients. Diabetes mellitus and hyperthyroidism are risk factors for death within 90 days, together with gastrointestinal bleeding and HE at admission, HE and hepatorenal syndrome during hospitalisation. Knowledge of risk factors can help identify HBV-ACLF patients with a poor prognosis for HBV-ACLF with comorbidities and complications. Cambridge University Press 2022-07-05 /pmc/articles/PMC9354478/ /pubmed/35788251 http://dx.doi.org/10.1017/S0950268822001169 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
spellingShingle Original Paper
Weng, Wei-zhen
Chen, Jun-feng
Peng, Xiao-hua
Huang, Miao
Zhang, Jing
Xiong, Jing
Cao, Hui-juan
Lin, Bing-liang
Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
title Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
title_full Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
title_fullStr Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
title_full_unstemmed Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
title_short Risk factors for underlying comorbidities and complications in patients with hepatitis B virus-related acute-on-chronic liver failure
title_sort risk factors for underlying comorbidities and complications in patients with hepatitis b virus-related acute-on-chronic liver failure
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354478/
https://www.ncbi.nlm.nih.gov/pubmed/35788251
http://dx.doi.org/10.1017/S0950268822001169
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