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Discovery of novel natural products as dual MNK/PIM inhibitors for acute myeloid leukemia treatment: Pharmacophore modeling, molecular docking, and molecular dynamics studies

MNK-2 and PIM-2 kinases play an indispensable role in cell proliferation signaling pathways linked to tyrosine kinase inhibitors resistance. In this study, pharmacophore modeling studies have been conducted on the co-crystalized ligands of MNK-2 and PIM-2 enzyme crystal structures to determine the e...

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Detalles Bibliográficos
Autores principales:	Mohamed, Linda M., Eltigani, Maha M., Abdallah, Marwa H., Ghaboosh, Hiba, Bin Jardan, Yousef A., Yusuf, Osman, Elsaman, Tilal, Mohamed, Magdi A., Alzain, Abdulrahim A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354516/ https://www.ncbi.nlm.nih.gov/pubmed/35936081 http://dx.doi.org/10.3389/fchem.2022.975191

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