Cargando…

The Combination of Radiotherapy and Complement C3a Inhibition Potentiates Natural Killer cell Functions Against Pancreatic Cancer

Pancreatic cancer is one of the deadliest cancers, against which current immunotherapy strategies are not effective. Herein, we analyzed the immune cell composition of the tumor microenvironment of pancreatic cancer samples in The Cancer Genome Atlas and found that the presence of intratumoral natur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sodji, Quaovi H., Nambiar, Dhanya K., Viswanathan, Vignesh, von Eyben, Rie, Colburg, Deana, Binkley, Michael S., Li, Caiyun G., Olcina, Monica M., Chang, Daniel T., Le, Quynh-Thu, Giaccia, Amato J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354534/ https://www.ncbi.nlm.nih.gov/pubmed/35937458 http://dx.doi.org/10.1158/2767-9764.CRC-22-0069

Ejemplares similares

Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis
por: Olcina, Monica M., et al.
Publicado: (2020)

The role of Glial cell derived neurotrophic factor in head and neck cancer
por: Cao, Hongbin, et al.
Publicado: (2020)

The tumour microenvironment links complement system dysregulation and hypoxic signalling
por: Olcina, Monica M, et al.
Publicado: (2019)

Tumor immunologic heterogeneity influences response to radiation and combination immunotherapy
por: Aguilera, Todd, et al.
Publicado: (2015)

Predictive role of PD-L1 expression in the response of renal Medullary carcinoma to PD-1 inhibition
por: Sodji, Quaovi, et al.
Publicado: (2017)

Inflammation, Fibrosis and Cancer: Mechanisms, Therapeutic Options and Challenges
por: Wu, Bocheng, et al.
Publicado: (2022)

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1
por: Beach, Callum, et al.
Publicado: (2023)

(68)Ga-PSMA PET/CT for Patients with PSA Relapse after Radical Prostatectomy or External Beam Radiotherapy
por: von Eyben, Finn Edler, et al.
Publicado: (2021)

KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage
por: Castellini, Laura, et al.
Publicado: (2017)

Selection of external beam radiotherapy approaches for precise and accurate cancer treatment
por: Shirato, Hiroki, et al.
Publicado: (2018)

Aldehyde dehydrogenase 3A1 activation prevents radiation-induced xerostomia by protecting salivary stem cells from toxic aldehydes
por: Saiki, Julie P., et al.
Publicado: (2018)

Predicting per-lesion local recurrence in locally advanced non-small cell lung cancer following definitive radiation therapy using pre- and mid-treatment metabolic tumor volume
por: Binkley, Michael S., et al.
Publicado: (2020)

FLT-PET-CT for the Detection of Disease Recurrence After Stereotactic Ablative Radiotherapy or Hyperfractionation for Thoracic Malignancy: A Prospective Pilot Study
por: Hiniker, Susan M., et al.
Publicado: (2019)

Syndrome of inappropriate secretion of antidiuretic hormone following high dose rate brachytherapy for prostate cancer: a case report
por: Ayoola, Adeoluwa, et al.
Publicado: (2022)

Aldehyde dehydrogenase 3A1 deficiency leads to mitochondrial dysfunction and impacts salivary gland stem cell phenotype
por: Viswanathan, Vignesh, et al.
Publicado: (2022)

Durability of response in metastatic melanoma patients after combined treatment with radiation therapy and ipilimumab
por: Sodji, Quaovi H, et al.
Publicado: (2020)

Evaluation of transperineal ultrasound imaging as a potential solution for target tracking during hypofractionated radiotherapy for prostate cancer
por: Han, Bin, et al.
Publicado: (2018)

Feasibility of optimizing intensity‐modulated radiation therapy plans based on measured mucosal dose adjacent to dental fillings and toxicity outcomes
por: Seol, Seung Won, et al.
Publicado: (2018)

Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation
por: Wu, Ping-Hsiu, et al.
Publicado: (2020)

Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer
por: Tailor, Dhanir, et al.
Publicado: (2020)

Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition
por: Wu, Ping-Hsiu, et al.
Publicado: (2019)

Validated limited gene predictor for cervical cancer lymph node metastases
por: Bloomstein, Joshua D., et al.
Publicado: (2020)

HIF‐2: The Missing Link Between Obesity and Cardiomyopathy
por: Giaccia, Amato J.
Publicado: (2013)

Reciprocal Complementation of the Tumoricidal Effects of Radiation and Natural Killer Cells
por: Yang, Kai-Lin, et al.
Publicado: (2013)

Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma
por: Nishioka, Soichiro, et al.
Publicado: (2020)

Pretest PSA and Restaging PSMA PET/CT Predict Survival in Biochemically Recurrent Prostate Cancer
por: von Eyben, Rie, et al.
Publicado: (2023)

Reprogramming the immunological microenvironment through radiation and targeting Axl
por: Aguilera, Todd A., et al.
Publicado: (2016)

Reirradiation with stereotactic body radiation therapy after prior conventional fractionation radiation for locally recurrent pancreatic adenocarcinoma
por: Koong, Amanda J., et al.
Publicado: (2017)

Medical Scribe Impact on Provider Efficiency in Outpatient Radiation Oncology Clinics Before and During the COVID-19 Pandemic
por: Devine, Max, et al.
Publicado: (2022)

Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1
por: Leszczynska, Katarzyna B., et al.
Publicado: (2016)

Thinking inside the box: intracellular roles for complement system proteins come into focus
por: O’Brien, Rebecca M., et al.
Publicado: (2023)

Cerebral venous thrombosis in refractory idiopathic thrombocytopenia treated with eltrombopag
por: Nambiar, Vivek, et al.
Publicado: (2016)

Pilot study of combined FDG‐PET and dynamic contrast‐enhanced CT of locally advanced cervical carcinoma before and during concurrent chemoradiotherapy suggests association between changes in tumor blood volume and treatment response
por: Banks, Thomas I., et al.
Publicado: (2018)

A Risk Model for Patients with PSA-Only Recurrence (Biochemical Recurrence) Based on PSA and PSMA PET/CT: An Individual Patient Data Meta-Analysis
por: von Eyben, Rie, et al.
Publicado: (2022)

Correction: von Eyben et al. A Risk Model for Patients with PSA-Only Recurrence (Biochemical Recurrence) Based on PSA and PSMA PET/CT: An Individual Patient Data Meta-Analysis. Cancers 2022, 14, 5461
por: von Eyben, Rie, et al.
Publicado: (2023)

Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer
por: Olcina, Monica M., et al.
Publicado: (2018)

A cross-sectional study describing factors associated with utilisation of GP services by a cohort of people who inject drugs
por: Nambiar, Dhanya, et al.
Publicado: (2014)

Optimizing PSMA Radioligand Therapy for Patients with Metastatic Castration-Resistant Prostate Cancer. A Systematic Review and Meta-Analysis
por: von Eyben, Finn Edler, et al.
Publicado: (2020)

Radiobiology for the Radiologist
por: Hall, Eric J, et al.
Publicado: (2011)

Radiobiology for the Radiologist
por: Hall, Eric J, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_0ev8sku4tkqcd17ba86pquv1hr