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Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention
Radiotherapy is part of the treatment for many thoracic cancers. During this treatment heart and lung tissue can often receive considerable doses of radiation. Doses to the heart can potentially lead to cardiac effects such as pericarditis and myocardial fibrosis. Common side effects after lung irra...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354542/ https://www.ncbi.nlm.nih.gov/pubmed/35936724 http://dx.doi.org/10.3389/fonc.2022.931023 |
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author | Wiedemann, Julia Coppes, Robert P. van Luijk, Peter |
author_facet | Wiedemann, Julia Coppes, Robert P. van Luijk, Peter |
author_sort | Wiedemann, Julia |
collection | PubMed |
description | Radiotherapy is part of the treatment for many thoracic cancers. During this treatment heart and lung tissue can often receive considerable doses of radiation. Doses to the heart can potentially lead to cardiac effects such as pericarditis and myocardial fibrosis. Common side effects after lung irradiation are pneumonitis and pulmonary fibrosis. It has also been shown that lung irradiation has effects on cardiac function. In a rat model lung irradiation caused remodeling of the pulmonary vasculature increasing resistance of the pulmonary vascular bed, leading to enhanced pulmonary artery pressure, right ventricle hypertrophy and reduced right ventricle performance. Even more pronounced effects are observed when both, lung and heart are irradiated. The effects observed after lung irradiation show striking similarities with symptoms of pulmonary arterial hypertension. In particular, the vascular remodeling in lung tissue seems to have similar underlying features. Here, we discuss the similarities and differences of vascular remodeling observed after thoracic irradiation compared to those in pulmonary arterial hypertension patients and research models. We will also assess how this knowledge of similarities could potentially be translated into interventions which would be beneficial for patients treated for thoracic tumors, where dose to lung tissue is often unavoidable. |
format | Online Article Text |
id | pubmed-9354542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93545422022-08-06 Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention Wiedemann, Julia Coppes, Robert P. van Luijk, Peter Front Oncol Oncology Radiotherapy is part of the treatment for many thoracic cancers. During this treatment heart and lung tissue can often receive considerable doses of radiation. Doses to the heart can potentially lead to cardiac effects such as pericarditis and myocardial fibrosis. Common side effects after lung irradiation are pneumonitis and pulmonary fibrosis. It has also been shown that lung irradiation has effects on cardiac function. In a rat model lung irradiation caused remodeling of the pulmonary vasculature increasing resistance of the pulmonary vascular bed, leading to enhanced pulmonary artery pressure, right ventricle hypertrophy and reduced right ventricle performance. Even more pronounced effects are observed when both, lung and heart are irradiated. The effects observed after lung irradiation show striking similarities with symptoms of pulmonary arterial hypertension. In particular, the vascular remodeling in lung tissue seems to have similar underlying features. Here, we discuss the similarities and differences of vascular remodeling observed after thoracic irradiation compared to those in pulmonary arterial hypertension patients and research models. We will also assess how this knowledge of similarities could potentially be translated into interventions which would be beneficial for patients treated for thoracic tumors, where dose to lung tissue is often unavoidable. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354542/ /pubmed/35936724 http://dx.doi.org/10.3389/fonc.2022.931023 Text en Copyright © 2022 Wiedemann, Coppes and van Luijk https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wiedemann, Julia Coppes, Robert P. van Luijk, Peter Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention |
title | Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention |
title_full | Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention |
title_fullStr | Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention |
title_full_unstemmed | Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention |
title_short | Radiation-induced cardiac side-effects: The lung as target for interacting damage and intervention |
title_sort | radiation-induced cardiac side-effects: the lung as target for interacting damage and intervention |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354542/ https://www.ncbi.nlm.nih.gov/pubmed/35936724 http://dx.doi.org/10.3389/fonc.2022.931023 |
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