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β-secretase inhibition prevents structural spine plasticity deficits in App(NL-G-F) mice

All clinical BACE1-inhibitor trials for the treatment of Alzheimer's Disease (AD) have failed due to insufficient efficacy or side effects like worsening of cognitive symptoms. However, the scientific evidence to date suggests that BACE1-inhibition could be an effective preventative measure if...

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Detalles Bibliográficos
Autores principales:	Blume, Tanja, Filser, Severin, Sgobio, Carmelo, Peters, Finn, Neumann, Ulf, Shimshek, Derya, Saito, Takashi, Saido, Takaomi C., Brendel, Matthias, Herms, Jochen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Aging Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354544/ https://www.ncbi.nlm.nih.gov/pubmed/35936777 http://dx.doi.org/10.3389/fnagi.2022.909586

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