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Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure
Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that am...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354609/ https://www.ncbi.nlm.nih.gov/pubmed/35936767 http://dx.doi.org/10.3389/fnagi.2022.934346 |
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author | Miyata, Shingo Ishino, Yugo Shimizu, Shoko Tohyama, Masaya |
author_facet | Miyata, Shingo Ishino, Yugo Shimizu, Shoko Tohyama, Masaya |
author_sort | Miyata, Shingo |
collection | PubMed |
description | Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that among many environmental factors, inflammation and immune abnormalities in the brain or the peripheral tissues are associated with the onset of MDDs. Furthermore, several stress-related hypotheses have been proposed to explain the onset of MDDs. Thus, inflammation or immune abnormalities can be considered stress responses that occur within the brain or other tissues and are regarded as one of the mechanisms underlying the stress hypothesis of MDDs. Therefore, we introduce several current advances in inflammation studies in the brain that might be related to the pathophysiology of MDD due to stress exposure in this review. |
format | Online Article Text |
id | pubmed-9354609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93546092022-08-06 Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure Miyata, Shingo Ishino, Yugo Shimizu, Shoko Tohyama, Masaya Front Aging Neurosci Aging Neuroscience Major depressive disorder (MDD) is a multifactorial disease affected by several environmental factors. Although several potential onset hypotheses have been identified, the molecular mechanisms underlying the pathogenesis of this disorder remain unclear. Several recent studies have suggested that among many environmental factors, inflammation and immune abnormalities in the brain or the peripheral tissues are associated with the onset of MDDs. Furthermore, several stress-related hypotheses have been proposed to explain the onset of MDDs. Thus, inflammation or immune abnormalities can be considered stress responses that occur within the brain or other tissues and are regarded as one of the mechanisms underlying the stress hypothesis of MDDs. Therefore, we introduce several current advances in inflammation studies in the brain that might be related to the pathophysiology of MDD due to stress exposure in this review. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354609/ /pubmed/35936767 http://dx.doi.org/10.3389/fnagi.2022.934346 Text en Copyright © 2022 Miyata, Ishino, Shimizu and Tohyama. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Aging Neuroscience Miyata, Shingo Ishino, Yugo Shimizu, Shoko Tohyama, Masaya Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
title | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
title_full | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
title_fullStr | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
title_full_unstemmed | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
title_short | Involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
title_sort | involvement of inflammatory responses in the brain to the onset of major depressive disorder due to stress exposure |
topic | Aging Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354609/ https://www.ncbi.nlm.nih.gov/pubmed/35936767 http://dx.doi.org/10.3389/fnagi.2022.934346 |
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