Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP

We recently described the identification of a new class of small‐molecule activators of the mitochondrial protease ClpP. These compounds synthesized by Madera Therapeutics showed increased potency of cancer growth inhibition over the related compound ONC201. In this study, we describe chemical optim...

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Detalles Bibliográficos
Autores principales: Fennell, Emily M. J., Aponte‐Collazo, Lucas J., Wynn, Joshua D., Drizyte‐Miller, Kristina, Leung, Elisa, Greer, Yoshimi Endo, Graves, Paul R., Iwanowicz, Andrew A., Ashamalla, Hani, Holmuhamedov, Ekhson, Lang, Henk, Karanewsky, Donald S., Der, Channing J., Houry, Walid A., Lipkowitz, Stanley, Iwanowicz, Edwin J., Graves, Lee M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354705/
https://www.ncbi.nlm.nih.gov/pubmed/35929764
http://dx.doi.org/10.1002/prp2.993

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