The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology

NKG2D is a major natural killer (NK) cell-activating receptor that recognizes eight ligands (NKG2DLs), including MICA, and whose engagement triggers NK cell effector functions. As NKG2DLs are upregulated on tumor cells but tumors can subvert the NKG2D-NKG2DL axis, NKG2DLs constitute attractive targe...

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Detalles Bibliográficos
Autores principales: Secchiari, Florencia, Nuñez, Sol Yanel, Sierra, Jessica Mariel, Ziblat, Andrea, Regge, María Victoria, Raffo Iraolagoitia, Ximena Lucía, Rovegno, Agustín, Ameri, Carlos, Secin, Fernando Pablo, Richards, Nicolás, Ríos Pita, Hernando, Vitagliano, Gonzalo, Rico, Luis, Mieggi, Mauro, Frascheri, Florencia, Bonanno, Nicolás, Blas, Leandro, Trotta, Aldana, Friedrich, Adrián David, Fuertes, Mercedes Beatriz, Domaica, Carolina Inés, Zwirner, Norberto Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354769/
https://www.ncbi.nlm.nih.gov/pubmed/35936986
http://dx.doi.org/10.1080/2162402X.2022.2104991

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