Cargando…

Discovery and engineering of an anti-TREM2 antibody to promote amyloid plaque clearance by microglia in 5XFAD mice

Triggering receptor expressed on myeloid cells 2 (TREM2) plays a crucial role in regulating microglial functions and removal of amyloid plaques in Alzheimer’s disease (AD). However, therapeutics based on this knowledge have not been developed due to the low antibody brain penetration and weak TREM2...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Peng, Xu, Yuanzhong, Fan, Xuejun, Li, Leike, Li, Xin, Arase, Hisashi, Tong, Qingchun, Zhang, Ningyan, An, Zhiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354770/ https://www.ncbi.nlm.nih.gov/pubmed/35921534 http://dx.doi.org/10.1080/19420862.2022.2107971

Ejemplares similares

LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions
por: Zhao, Peng, et al.
Publicado: (2022)

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease
por: Lee, Jiyeon, et al.
Publicado: (2019)

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition
por: Price, Brittani R., et al.
Publicado: (2020)

Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice
por: Delizannis, Argyro Thalia, et al.
Publicado: (2021)

Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia
por: Zhao, Na, et al.
Publicado: (2022)

TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
por: Xiang, Xianyuan, et al.
Publicado: (2016)

APOE and TREM2 regulate amyloid responsive microglia in Alzheimer’s disease
por: Nguyen, Aivi T., et al.
Publicado: (2020)

IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia
por: Rivera-Escalera, Fátima, et al.
Publicado: (2019)

Brain Region-Specific Differences in Amyloid-β Plaque Composition in 5XFAD Mice
por: Bader, Angelika Sabine, et al.
Publicado: (2023)

Forebrain microglia from wild-type but not adult 5xFAD mice prevent amyloid-β plaque formation in organotypic hippocampal slice cultures
por: Hellwig, Sabine, et al.
Publicado: (2015)

The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer’s disease
por: von Saucken, Victoria E., et al.
Publicado: (2020)

TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
por: Cignarella, Francesca, et al.
Publicado: (2020)

Quinacrine directly dissociates amyloid plaques in the brain of 5XFAD transgenic mouse model of Alzheimer’s disease
por: Park, Sohui, et al.
Publicado: (2021)

Cyclopentanone Derivative Attenuates Memory Impairment by Inhibiting Amyloid Plaques Formation in the 5xFAD Mice
por: Ullah, Rahim, et al.
Publicado: (2021)

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
por: Wang, Yaming, et al.
Publicado: (2016)

Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer’s disease mouse model with suppression of glymphatic clearance
por: Feng, Weixi, et al.
Publicado: (2020)

The effect of electroconvulsive therapy on neuroinflammation, behavior and amyloid plaques in the 5xFAD mouse model of Alzheimer’s disease
por: Svensson, Martina, et al.
Publicado: (2021)

Thioflavin-positive tau aggregates complicating quantification of amyloid plaques in the brain of 5XFAD transgenic mouse model
por: Shin, Jisu, et al.
Publicado: (2021)

Increased tauopathy drives microglia-mediated clearance of beta-amyloid
por: Chen, Wesley, et al.
Publicado: (2016)

Loss of TREM2 function increases amyloid seeding but reduces plaque associated ApoE
por: Parhizkar, Samira, et al.
Publicado: (2019)

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation
por: Ewers, Michael, et al.
Publicado: (2020)

High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice
por: Kook, S-Y, et al.
Publicado: (2014)

Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer’s disease
por: Tsui, Ka Chun, et al.
Publicado: (2022)

Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer’s Disease Mouse Model
por: Yuan, Qiuju, et al.
Publicado: (2021)

Enhanced anti-angiogenetic effect of transferrin receptor-mediated delivery of VEGF-trap in a glioblastoma mouse model
por: Zhao, Peng, et al.
Publicado: (2022)

Microglia use TAM receptors to detect and engulf amyloid beta plaques
por: Huang, Youtong, et al.
Publicado: (2021)

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease
por: Zhou, Yingyue, et al.
Publicado: (2018)

T Cells Specifically Targeted to Amyloid Plaques Enhance Plaque Clearance in a Mouse Model of Alzheimer's Disease
por: Fisher, Yair, et al.
Publicado: (2010)

LRP1 plays a major role in the amyloid-β clearance in microglia
por: N’Songo, Aurelie, et al.
Publicado: (2013)

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Whitmore, Clayton A., et al.
Publicado: (2022)

Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

Data on TREM-1 activation destabilizing carotid plaques
por: Rao, Velidi H., et al.
Publicado: (2016)

Microglia limit the expansion of β-amyloid plaques in a mouse model of Alzheimer’s disease
por: Zhao, Ruohe, et al.
Publicado: (2017)

Jowiseungchungtang Inhibits Amyloid-β Aggregation and Amyloid-β-Mediated Pathology in 5XFAD Mice
por: Shin, Soo Jung, et al.
Publicado: (2018)

Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model
por: Kim, DaWon, et al.
Publicado: (2020)

Correction: Detection of β-amyloid aggregates/plaques in 5xFAD mice by labelled native PLGA nanoparticles: implication in the diagnosis of Alzheimer’s disease
por: Govindarajan, Karthivashan, et al.
Publicado: (2023)

Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
por: Sadleir, Katherine R., et al.
Publicado: (2021)

Microglia control small vessel calcification via TREM2
por: Zarb, Yvette, et al.
Publicado: (2021)

Reduced TREM2 activation in microglia of patients with Alzheimer's disease
por: Okuzono, Yuumi, et al.
Publicado: (2021)

TREM2 dependent and independent functions of microglia in Alzheimer’s disease
por: Hou, Jinchao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1md3h55f9kfpaf9dn0mrf32rau