Optimizing Epitope Conformational Ensembles Using α-Synuclein Cyclic Peptide “Glycindel” Scaffolds: A Customized Immunogen Method for Generating Oligomer-Selective Antibodies for Parkinson’s Disease

[Image: see text] Effectively presenting epitopes on immunogens, in order to raise conformationally selective antibodies through active immunization, is a central problem in treating protein misfolding diseases, particularly neurodegenerative diseases such as Alzheimer’s disease or Parkinson’s disea...

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Detalles Bibliográficos
Autores principales: Hsueh, Shawn C. C., Aina, Adekunle, Roman, Andrei Yu., Cashman, Neil R., Peng, Xubiao, Plotkin, Steven S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354795/
https://www.ncbi.nlm.nih.gov/pubmed/35840132
http://dx.doi.org/10.1021/acschemneuro.1c00567

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