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Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration

BACKGROUND: Intervertebral disc degeneration (IVDD) is closely associated with senescence. Annulus fibrosus (AF) cell senescence is a crucial driver of AF tissue tearing and fissures, thereby exacerbating IVDD. Increased advanced oxidative protein products (AOPPs) were found in human degenerative di...

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Detalles Bibliográficos
Autores principales:	Dai, Xiangheng, Chen, Yu, Yu, Zihan, Liao, Congrui, Liu, Zhongyuan, Chen, Jianting, Wu, Qian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2022
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354796/ https://www.ncbi.nlm.nih.gov/pubmed/35935259 http://dx.doi.org/10.7717/peerj.13826

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