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A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects
The regeneration of critical-size bone defects on long bones has remained a significant challenge because of the complex anatomical structure and vascular network. In such circumstances, current biomaterial forms with homogeneous structure and function can hardly satisfy the need for both osteogenes...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354842/ https://www.ncbi.nlm.nih.gov/pubmed/35935476 http://dx.doi.org/10.3389/fbioe.2022.927050 |
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author | Wang, Lingjun Mao, Jiannan Cai, Feng Tang, Jincheng Xi, Kun Feng, Yu Xu, Yichang Liang, Xiao Gu, Yong Chen, Liang |
author_facet | Wang, Lingjun Mao, Jiannan Cai, Feng Tang, Jincheng Xi, Kun Feng, Yu Xu, Yichang Liang, Xiao Gu, Yong Chen, Liang |
author_sort | Wang, Lingjun |
collection | PubMed |
description | The regeneration of critical-size bone defects on long bones has remained a significant challenge because of the complex anatomical structure and vascular network. In such circumstances, current biomaterial forms with homogeneous structure and function can hardly satisfy the need for both osteogenesis and angiogenesis. In the current study, a heterogeneous biomimetic structured scaffold was constructed with the help of a 3D printed mold to simultaneously mimic the outer/inner periosteum and intermediate bone matrix of a natural long bone. Because of the reinforcement via modified mesoporous bioactive glass nanoparticles (MBGNs), enhanced structural stability and adequate osteogenic capacity could be achieved for the intermediate layer of this scaffold. Conversely, GelMA incorporated with VEGF-loaded liposome exhibiting controlled release of the angiogenic factor was applied to the inner and outer layers of the scaffold. The resulting heterogeneous structured scaffold was shown to successfully guide bone regeneration and restoration of the natural bone anatomic structure, rendering it a promising candidate for future orthopedic clinical studies. |
format | Online Article Text |
id | pubmed-9354842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93548422022-08-06 A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects Wang, Lingjun Mao, Jiannan Cai, Feng Tang, Jincheng Xi, Kun Feng, Yu Xu, Yichang Liang, Xiao Gu, Yong Chen, Liang Front Bioeng Biotechnol Bioengineering and Biotechnology The regeneration of critical-size bone defects on long bones has remained a significant challenge because of the complex anatomical structure and vascular network. In such circumstances, current biomaterial forms with homogeneous structure and function can hardly satisfy the need for both osteogenesis and angiogenesis. In the current study, a heterogeneous biomimetic structured scaffold was constructed with the help of a 3D printed mold to simultaneously mimic the outer/inner periosteum and intermediate bone matrix of a natural long bone. Because of the reinforcement via modified mesoporous bioactive glass nanoparticles (MBGNs), enhanced structural stability and adequate osteogenic capacity could be achieved for the intermediate layer of this scaffold. Conversely, GelMA incorporated with VEGF-loaded liposome exhibiting controlled release of the angiogenic factor was applied to the inner and outer layers of the scaffold. The resulting heterogeneous structured scaffold was shown to successfully guide bone regeneration and restoration of the natural bone anatomic structure, rendering it a promising candidate for future orthopedic clinical studies. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354842/ /pubmed/35935476 http://dx.doi.org/10.3389/fbioe.2022.927050 Text en Copyright © 2022 Wang, Mao, Cai, Tang, Xi, Feng, Xu, Liang, Gu and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wang, Lingjun Mao, Jiannan Cai, Feng Tang, Jincheng Xi, Kun Feng, Yu Xu, Yichang Liang, Xiao Gu, Yong Chen, Liang A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects |
title | A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects |
title_full | A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects |
title_fullStr | A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects |
title_full_unstemmed | A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects |
title_short | A Structured Scaffold Featuring Biomimetic Heterogeneous Architecture for the Regeneration of Critical-Size Bone Defects |
title_sort | structured scaffold featuring biomimetic heterogeneous architecture for the regeneration of critical-size bone defects |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354842/ https://www.ncbi.nlm.nih.gov/pubmed/35935476 http://dx.doi.org/10.3389/fbioe.2022.927050 |
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