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Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review
Colorectal cancer (CRC) is a global public health concern because of its high prevalence and mortality. Although radiotherapy is a key method for treating CRC, radioresistance is an obstacle to radiotherapy use. The molecular mechanisms underlying the radioresistance of CRC remain unclear. Increasin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354854/ https://www.ncbi.nlm.nih.gov/pubmed/35936676 http://dx.doi.org/10.3389/fonc.2022.889658 |
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author | Huang, Chun-Ming Tsai, Hsiang-Lin Chen, Yen-Cheng Huang, Ching-Wen Li, Ching-Chun Su, Wei-Chih Chang, Tsung-Kun Yeh, Yung-Sung Chen, Po-Jung Huang, Ming-Yii Wang, Jaw-Yuan |
author_facet | Huang, Chun-Ming Tsai, Hsiang-Lin Chen, Yen-Cheng Huang, Ching-Wen Li, Ching-Chun Su, Wei-Chih Chang, Tsung-Kun Yeh, Yung-Sung Chen, Po-Jung Huang, Ming-Yii Wang, Jaw-Yuan |
author_sort | Huang, Chun-Ming |
collection | PubMed |
description | Colorectal cancer (CRC) is a global public health concern because of its high prevalence and mortality. Although radiotherapy is a key method for treating CRC, radioresistance is an obstacle to radiotherapy use. The molecular mechanisms underlying the radioresistance of CRC remain unclear. Increasing evidence has revealed the multiple regulatory functions of non-coding RNAs (ncRNAs) in numerous malignancies, including CRC. Several ncRNAs have been reported to be involved in the determination of radiosensitivity of CRC cells, and some have excellent potential to be prognostic biomarkers or therapeutic targets in CRC treatment. The present review discusses the biological functions and underlying mechanisms of ncRNAs (primarily lncRNA, miRNA, and circRNA) in the regulation of the radiosensitivity of CRC. We also evaluate studies that examined ncRNAs as biomarkers of response to radiation and as therapeutic targets for enhancing radiosensitivity. |
format | Online Article Text |
id | pubmed-9354854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93548542022-08-06 Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review Huang, Chun-Ming Tsai, Hsiang-Lin Chen, Yen-Cheng Huang, Ching-Wen Li, Ching-Chun Su, Wei-Chih Chang, Tsung-Kun Yeh, Yung-Sung Chen, Po-Jung Huang, Ming-Yii Wang, Jaw-Yuan Front Oncol Oncology Colorectal cancer (CRC) is a global public health concern because of its high prevalence and mortality. Although radiotherapy is a key method for treating CRC, radioresistance is an obstacle to radiotherapy use. The molecular mechanisms underlying the radioresistance of CRC remain unclear. Increasing evidence has revealed the multiple regulatory functions of non-coding RNAs (ncRNAs) in numerous malignancies, including CRC. Several ncRNAs have been reported to be involved in the determination of radiosensitivity of CRC cells, and some have excellent potential to be prognostic biomarkers or therapeutic targets in CRC treatment. The present review discusses the biological functions and underlying mechanisms of ncRNAs (primarily lncRNA, miRNA, and circRNA) in the regulation of the radiosensitivity of CRC. We also evaluate studies that examined ncRNAs as biomarkers of response to radiation and as therapeutic targets for enhancing radiosensitivity. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9354854/ /pubmed/35936676 http://dx.doi.org/10.3389/fonc.2022.889658 Text en Copyright © 2022 Huang, Tsai, Chen, Huang, Li, Su, Chang, Yeh, Chen, Huang and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Huang, Chun-Ming Tsai, Hsiang-Lin Chen, Yen-Cheng Huang, Ching-Wen Li, Ching-Chun Su, Wei-Chih Chang, Tsung-Kun Yeh, Yung-Sung Chen, Po-Jung Huang, Ming-Yii Wang, Jaw-Yuan Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review |
title | Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review |
title_full | Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review |
title_fullStr | Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review |
title_full_unstemmed | Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review |
title_short | Role of non-coding RNAs in radiosensitivity of colorectal cancer: A narrative review |
title_sort | role of non-coding rnas in radiosensitivity of colorectal cancer: a narrative review |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9354854/ https://www.ncbi.nlm.nih.gov/pubmed/35936676 http://dx.doi.org/10.3389/fonc.2022.889658 |
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